The recent discovery of competitive endogenous RNAs (ceRNA), natural decoys that compete for a common pool of miRNAs, provides a framework to systematically functionalize MRE-harboring noncoding RNAs and integrate them with the protein-coding RNA dimension in complex ceRNA networks. Functional interactions in ceRNA networks aid in coordinating a number of biologic processes and, when perturbed, contribute

to disease pathogenesis. In this review, we discuss recent discoveries that implicate natural miRNA decoys in the development of cancer.\n\nSignificance: Cross-talk between ceRNAs through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such Volasertib as cancer. As cross-talk can be predicted on the basis of the overlap of miRNA-binding

sites, we are now one step closer to a complete functionalization of the human transcriptome, especially the noncoding space. (C) 2013 AACR.”
“Variational transition state theory calculations with the correction of multidimensional tunneling are performed on a 12-dimensional ab initio potential energy surface for the H + SiH4 abstraction reaction. The surface is constructed using a dual-level strategy. For the temperature range 200-1600 K, thermal rate constants are calculated and kinetic isotope effects for various isotopic species of the title reaction are investigated. The results are in very good agreement with available experimental data. (C) 2011 RSL3 concentration American Institute of Physics. [doi:10.1063/1.3521477]“
“This study represents the first survey of the parasitic fauna of cetaceans off the northeastern coast of Brazil. Parasites were collected from 82 animals rescued from the states of Ceara to Bahia, including the archipelago of Fernando de Noronha. A total of 14 species of cetaceans were evaluated: Sotalia guianensis, Stenella sp., Stenella clymene, Stenella longirostris, Stenella coeruleoalba, Stenella frontalis, Megaptera novaeangliae, Peponocephala elect no, Steno bredanensis, Kogia Saracatinib ic50 breviceps, Kogia sima, Globicephala macrorhynchus, Tursiops truncatus, Physeter macrocephalus and Lagenodelphis

hosei. The parasites were fixed and preserved in 70% ethanol or alcohol-formalin-acetic acid solution (AFA), clarified in phenol and mounted on slides for morphological identification. In total, 11 species and 8 genera of endo- and ectoparasites were identified: Halocercus brasiliensis, Halocercus kleinenbergi, Stenurus globicephalae, Halocercus sp., Anisakis sp., Crassicauda sp. (Nematoda), Phyllobothrium delphini, Monorygma grimaldii, Scolex pleuronectis, Strobicephalus triangularis, Tetrabothrius forsteri, Tetrabothrius sp., Trigonocotyle sp., Diphyllobothrium sp. (Cestoda), Corn pub sp. (Trematoda), Bolbosoma sp. (Acanthocephala), Cyamus boopis, Syncyamus pseudorcae and Xenobalanus globicipitis (Crustacea).

Although the alpha-amylase from the resistant cost strain exhibited higher affinity selleck chemical to starch (i.e., lower K(m)), its V(max)-value was the lowest among the strains, particularly the resistant no-cost strain. Such results provide support for the hypothesis that enhanced alpha-amylase activity may be playing a major role in mitigating fitness costs associated with insecticide resistance. (C) 2010 Elsevier Ltd. All rights reserved.”
“GOJANOVIC, B., J. WELKER, K. IGLESIAS, C. DAUCOURT, and G. GREMION. Electric Bicycles as a New Active Transportation Modality to

Promote Health. Med. Sci. Sports Exerc., Vol. 43, No. 11, pp. 2204-2210, 2011. Electrically assisted bicycles (EAB) are an emerging transportation modality favored for environmental reasons. Some physical effort is required to activate the supporting engine, making it a potential active commuting option. Purpose: We hypothesized that using an EAB in a hilly city allows sedentary subjects to commute comfortably, selleck products while providing a sufficient effort

for health-enhancing purposes. Methods: Sedentary subjects performed four different trips at a self-selected pace: walking 1.7 km uphill from the train station to the hospital (WALK), biking 5.1 km from the lower part of town to the hospital with a regular bike (BIKE), or EAB at two different power assistance settings (EAB(high), EAB(std)). HR, oxygen consumption, and need to shower were recorded. Results: Eighteen sedentary subjects (12 female, 6 male) age 36 +/- 10 yr

were included, with (V) over dotO(2max) of 39.4 +/- 5.4 mL.min(-1).kg(-1). Time to complete the course was 22 (WALK), 19 (EAB(high)), 21 (EAB(std)), JQ-EZ-05 cell line and 30 (BIKE) min. Mean %(V) over dotO(2max) was 59.0%, 54.9%, 65.7%, and 72.8%. Mean%HRmax was 71.5%, 74.5%, 80.3%, and 84.0%. There was no significant difference between WALK and EAB(high), but all other comparisons were different (P < 0.05). Two subjects needed to shower after EAB(high), 3 needed to shower after WALK, 8 needed to shower after EAB(std), and all 18 needed to shower after BIKE. WALK and EAB(high) elicited 6.5 and 6.1 METs (no difference), whereas it was 7.3 and 8.2 for EAB(std) and BIKE. Conclusions: EAB is a comfortable and ecological transportation modality, helping sedentary people commute to work and meet physical activity guidelines. Subjects appreciated ease of use and mild effort needed to activate the engine support climbing hills, without the need to shower at work. EAB can be promoted in a challenging urban environment to promote physical activity and mitigate pollution issues.”
“Previous animal and human studies have suggested that total plasma sulfide plays a role in the pathophysiology of shock. This study’s aim was to determine the value of total plasma sulfide as a marker of shock severity in nonsurgical adult patients admitted to the ICU.

\n\nDesign: Longitudinal population study.\n\nSetting: Community living subjects in Hong Kong.\n\nSubjects: One thousand and ten Chinese subjects participating in a territory wide dietary and cardiovascular risk factor prevalence survey in 1995 – 1996 were followed up for 5 – 9 years.\n\nMeasurements:

Body mass index (BMI) was measured. Information was collected on factors predisposing to development of overweight and obesity (age, gender, education level, physical activity, macronutrient intake, Mediterranean diet score and food variety), and the predisposing dietary factors examined, adjusted for other confounding factors, using logistic regression.\n\nResults: Selleckchem Ganetespib The 5 – 9- year incidence of overweight is 22.6% (BMI >= 23 kg/m(2), 95% confidence interval (CI)=d 15.0 – 30.1%) or 11.5% (BMI >= 25 kg/m(2), 95% CI = 7.3 – 15.7%), and for obesity (BMI >= 30 kg/m(2)) is 0.6% (95% CI = 0.2 – 1.4%). The corresponding figures for women were 14.1% (95% CI = 8.8 – 19.5%), 9.7% (95% CI = 6.0 – 13.4%) and 3% (95% CI = 1.3 4.8%). After adjusting for confounding factors (age, sex, education and physical activity), increased

variety of snack consumption was associated with increased risk of developing overweight (BMI >= 23 kg/m(2)) in the Hong Kong buy MGCD0103 Chinese population over a 5 – 9- year period.\n\nConclusion: Increased variety of snack consumption may predispose to weight gain over a 5 – 9- year period.”
“Background/Aims: The reasons for lower health-related quality of life (HRQOL) scores in women compared to men on maintenance hemodialysis (MHD) are unknown. We investigated whether depression accounts for gender differences in HRQOL. Methods: Cross-sectional study of 868 (40.9% women) Brazilian MHD patients (PROHEMO Study). We used the Kidney Disease Quality of Life Short Form to assess HRQOL and the Center for Epidemiological Studies Depression (CES-D) scale (scores from 0-60) to assess depression with scores 6 18 indicating high depression probability. Results: Higher depression

scores were associated with lower HRQOL in both sexes. Women had higher depression scores; 51.8% of women versus 38.2% of men (p < 0.001) Danusertib concentration had CES-D scores >= 18. Women scored lower on all 9 assessed HRQOL scales. The female-to-male differences in HRQOL were slightly reduced with inclusion of Kt/V and comorbidities in regression models. Substantial additional reductions in female-to-male differences in all HRQOL scales were observed after including depression scores in the models, by 50.9% for symptoms/problems related to renal failure, by 71.6% for mental health and by 87.1% for energy/vitality. Conclusions: Lower HRQOL among women was largely explained by depression symptoms. Results support greater emphasis on treating depression to improve HRQOL in MHD patients, particularly women. Copyright (c) 2010 S.

03) compared to the classical liquid ICG soldering technique.\n\nConclusion: Using nanoshells, controlled amounts of chromophore could successfully be bound into the polymer scaffold. Diode laser soldering of vascular tissue using ICG-nanoshell

scaffolds leads to strong and reproducible tissue fusion. With optimally chosen settings of irradiation time, nanoshells coating and scaffold properties, our improved LTS procedure demonstrates the potential for a clinically applicable anastomosis technique. Lasers Surg. Med. 43: 975-983, 2011. (C) 2011 Wiley Periodicals, Inc.”
“The study of sudden cardiac death (SCD) in athletes has received more interest in the medical and lay press over the past few years. Professional athletes represent ideals of fitness and health, and the sudden death of prominent athletes can come as a shock.

Underlying occult click here cardiovascular disorders are the most common cause of SCD in athletes. Unfortunately, because these disorders rarely present clinically, their initial manifestation is often a fatal event. Due to this, much attention has turned to both primary and secondary prevention. Primary prevention includes preparticipation screening and secondary prevention includes having automatic external defibrillators available at sporting events. This article summarizes the most common causes of athletic-related cardiac arrest and evaluates the screening www.selleckchem.com/products/salubrinal.html methods used to screen for these conditions. The general sentiment is that we need to more effectively identify athletes who are at risk for SCD, but how to do so using an efficient screening system and in a cost-effective manner have not been determined.”
“The neurotransmitter

serotonin underlies many of the brain’s functions. Understanding serotonin neurochemistry is important for improving treatments for neuropsychiatric disorders such as depression. Antidepressants commonly target Pevonedistat serotonin clearance via serotonin transporters and have variable clinical effects. Adjunctive therapies, targeting other systems including serotonin autoreceptors, also vary clinically and carry adverse consequences. Fast scan cyclic voltammetry is particularly well suited for studying antidepressant effects on serotonin clearance and autoreceptors by providing real-time chemical information on serotonin kinetics in vivo. However, the complex nature of in vivo serotonin responses makes it difficult to interpret experimental data with established kinetic models. Here, we electrically stimulated the mouse medial forebrain bundle to provoke and detect terminal serotonin in the substantia nigra reticulata. In response to medial forebrain bundle stimulation we found three dynamically distinct serotonin signals.

Exerc. Sport Sci. Rev., Vol. 38, No. 1, pp. 3-9, 2010. Recent studies on the neural bases of sensorimotor adaptation demonstrate that the cerebellar and striatal thalamocortical pathways contribute to early learning. Transfer of learning involves a reduction in the contribution of early learning networks and increased reliance on the cerebellum.

The neural correlates of teaming to team remain to be determined selleck chemicals but likely involve enhanced functioning of the general aspects of early teaming.”
“Purpose: (1) To determine the current bacteriological spectrum in connatal and acquired lacrimal duct obstruction (cLDO and aLDO, respectively) and (2) to analyze the antimicrobial susceptibility patterns of the recovered isolates. Materials and Methods: In a prospective study, 463 samples (30% bilateral LDO) were obtained from the lacrimal ducts of 132 infants and 192 adult patients with symptomatic LDO between 2007 and 2012 at a tertiary eye-care center. The samples were cultured for aerobic and anaerobic bacteria, which were subsequently identified using

standard microbiological techniques. Antimicrobial susceptibility testing was performed for each isolate using the disk diffusion method. Data were analyzed using SPSS and chi-square test for significance testing. Results: (1) Among 463 samples investigated, 333 samples were positive, i.e. at least one bacterial isolate was recovered. A total of 72% were recovered (97% of samples from children and 56% of samples from adults), yielding a total of 654 bacterial Selleckchem SNX-5422 isolates. Co-colonization with up to five different bacterial species AL3818 was observed in a large proportion of the samples from children (87%), but in only 20% of those from adults and with a maximum of three different bacteria. Gram-positive bacteria were identified in 72% of the positive samples in both aLDO and cLDO. The most common Gram-positive species in cLDO was Streptococcus pneumoniae (29%), while that in cLDO was Staphylococcus aureus (60%). The most prevalent Gram-negative species were Moraxella catarrhalis (8%) and Haemophilus influenzae (9%) in cLDO and Pseudomonas aeruginosa in aLDO

(12%). (2) Susceptibility testing revealed chloramphenicol to be the most active antibiotic with resistance rates of 3% in cLDO and 6% in aLDO, followed by ciprofloxacin (1% and 6%). Erythromycin and gentamicin were the least active of all, with resistances of 41% and 22%, respectively, in cLDO, and 23% and 11% in aLDO. Conclusions: Bacterial colonization occurs regularly in LDO, with Gram-positive bacteria being found in 97% of cLDO samples and 56% of aLDO samples. A remarkable number of different species were found to co-colonize in cLDO. The most common bacteria in LDO are highly susceptible in vitro to chloramphenicol and ciprofloxacin.”
“Definitive surface markers for retinal progenitor cells (RPCs) are still lacking.

Therefore, part of the efforts to reduce the disabling effects of depression should focus on preventing recurrence, especially in patients at high risk of recurrence. The best established effective psychological intervention is cognitive therapy, with BI 6727 mw indications for prophylactic effects after remission. Methods/Design: In this randomized controlled trial (cost-) effectiveness of Preventive Cognitive Therapy (PCT) after response to Acute Cognitive Therapy (A-CT) will be evaluated in comparison with Treatment As Usual (TAU). Remitted patients

that responded to A-CT treatment with at least two previous depressive episodes will be recruited. Randomization will be stratified for number of previous episodes. Follow-ups are at 3, 6, 12 and 15 months. The primary outcome measure will be the time to relapse or recurrence of depression meeting CCI-779 DSM-IV criteria for a major depressive episode on the Structured Clinical Interview for DSM-VI Axis I Disorders (SCID-I). Costs will be measured from a societal perspective. Discussion: This study is the first to examine the addition of PCT to TAU, compared to

TAU alone in patients that recovered from depressive disorder with A-CT. Alongside this effect study a cost effectiveness analysis will be conducted. Furthermore, the study explores potential moderators to examine what works for whom.”
“Arterial stiffness is a prominent feature of vascular aging and is strongly selleck chemical related to cardiovascular

disease. Oxidized low-density lipoprotein (ox-LDL), a key player in the pathogenesis of atherosclerosis, may also play a role in arterial stiffening, but this relationship has not been well studied. Thus, we examined the cross-sectional association between ox-LDL and aortic pulse wave velocity (aPWV), a marker of arterial stiffness, in community-dwelling older adults. Plasma ox-LDL levels and aPWV were measured in 2295 participants (mean age: 74 years; 52% female; 40% black) from the Health, Aging, and Body Composition Study. Mean aPWV significantly increased across tertiles of ox-LDL (tertile 1: 869 +/- 376 cm/s; tertile 2: 901 +/- 394 cm/s; tertile 3: 938 +/- 415 cm/s; P=0.002). In multivariate analyses, ox-LDL remained associated with aPWV after adjustment for demographics and traditional cardiovascular disease risk factors (P=0.008). After further adjustment for hemoglobin A1c, abdominal visceral fat, antihypertensive and antilipemic medications, and C-reactive protein, the association with ox-LDL was attenuated but remained significant (P=0.01). Results were similar when ox-LDL was expressed in absolute (milligrams per deciliter) or relative amounts (percentage of low-density lipoprotein). Moreover, individuals in the highest ox-LDL tertile were 30% to 55% more likely to have high arterial stiffness, defined as aPWV >75th percentile (P <= 0.02).

The activity Vorinostat cell line of RBR depends on phosphorylation of certain amino acid residues, which in most cases are well conserved between plant and animal proteins. In addition to its role in cell-cycle progression, RBR has been shown to participate in various cellular processes such as endoreplication, transcriptional regulation, chromatin remodelling, cell growth, stem cell biology, and differentiation. Here,

we discuss the most recent advances to define the role of RBR in cell proliferation and asymmetric cell division. These and other reports clearly support the idea that RBR is used as a landing platform of a plethora of cellular proteins and complexes to control various aspects of cell physiology and plant development.”
“A new type of nucleic acid analogues with a phosphoryl guanidine group is described. Oxidation of polymer-supported dinucleoside 2-cyanoethyl phosphite by iodine in the presence of 1,1,3,3-tetramethyl guanidine yields a dinucleotide with an internucleoside

tetramethyl phosphoryl guanidine (Tmg) group as the main product. The Tmg group is stable under conditions of solid-phase DNA synthesis and subsequent cleavage and deprotection with ammonia. Oligonucleotides with one or more Tmg groups bind their complementary DNA or RNA with affinity similar to that of natural oligodeoxyribonucleotides.”
“The microsporidian Nosema ceranae is an emergent pathogen that threatens the health of honeybees and other pollinators all over the world. Its recent rapid spread across a wide variety of host species and environments demonstrated an enhanced Quisinostat price ability learn more of adaptation, which seems to contradict the lack of evidence for genetic recombination and the

absence of a sexual stage in its life cycle. Here we retrieved fresh data of the patterns of genetic variation at the PTP2 locus in naturally infected Apis mellifera colonies, by means of single genome amplification. This technique, designed to prevent the formation of chimeric haplotypes during polymerase chain reaction (PCR), provides more reliable estimates of the diversity levels and haplotype structure than standard PCR-cloning methods. Our results are consistent with low but significant rates of recombination in the history of the haplotypes detected: estimates of the population recombination rate are of the order of 30 and support recent evidence for unexpectedly high levels of variation of the parasites within honeybee colonies. These observations suggest the existence of a diploid stage at some point in the life cycle of this parasite and are relevant for our understanding of the dynamics of its expanding population.”
“Structured Abstract ObjectivesTo evaluate sexual dimorphism of facial form and shape and to describe differences between the average female and male face from 12 to 15years.

Maxilla has been reported to be involved very rarely. Desmoplastic fibroma is recently being considered

to be one of the oral manifestations of tuberous sclerosis rather than a coincidental finding. We report an unusual case of a girl with a previous diagnosis of tuberosclerosis GSK2118436 clinical trial who presented at 8 years with an oral lesion diagnosed as desmoplastic fibroma.”
“Paramecia have many benefits in a biology classroom. They provide educational opportunities for students to learn about protists. Viewing paramecia allows students to observe organelles such as contractile vacuoles, food vacuoles, oral grooves, trichocysts, and macronuclei. The organism can be cultured easily and inexpensively using a plastic food container, wheat seeds, brewer’s yeast, a standard aquarium, and a tank heater. An individual culture can typically last 2 to 3 weeks, and sometimes up to a month. Using this simple culturing method, a constant, on-demand supply of paramecia can be available in any biology classroom. This, coupled with the ability to concentrate paramecia, opens the door to a wide variety of laboratory applications.”
“Chlorthalidone (CTD) is an antihypertensive SNS-032 cost drug and exhibits four crystalline forms: I, II, III and IV. In this paper, the incidence of CTD polymorphs in raw materials and in tablets as well as the solubility and dissolution properties of forms I and II have been studied. Raw materials

were named as A, B, C, D, and E and tablets as Reference, G1, G2 and S. Using powder X-ray diffraction and infrared spectroscopy analyses we found that A, B, E, Reference and G1 contain CTD form I; C, D and S contain predominantly form II; and G2 contain a mixture of both forms. Solubility experiments showed that form H is up to 49% more soluble than form land dissolution studies showed a significantly effect of the polymorphism on the dissolution of CTD from tablets. Based on these results, it was concluded that only the CTD form I is acceptable for preparation of tablet form. Moreover, we proposed the polymorphic quality control of CTD raw materials

and tablets. (C) 2013 Elsevier B.V. All rights reserved.”
“Staphylococcus aureus belongs to one of the most common bacteria causing healthcare and community associated BI-2536 infections in China, but their molecular characterization has not been well studied. From May 2011 to June 2012, a total of 322 non-duplicate S. aureus isolates were consecutively collected from seven tertiary care hospitals in seven cities with distinct geographical locations in China, including 171 methicillin sensitive S. aureus (MSSA) and 151 MRSA isolates. All isolates were characterized by spa typing. The presence of virulence genes was tested by PCR. MRSA were further characterized by SCCmec typing. Seventy four and 16 spa types were identified among 168 MSSA and 150 MRSA, respectively. One spa type t030 accounted for 80.

However, it did not inhibit neither the uptake of D-galactose by brush border membrane vesicles nor modified the SGLT1 protein levels in Adriamycin manufacturer the brush border, suggesting an indirect endotoxin effect. This inhibitory effect, was reduced by selective inhibitors of Ca(2+)- calmodulin (W13), protein kinase C (GF 109203X), p38 mitogen-activated protein kinase (SB 203580), c-Jun N-terminal kinase (SP 600125) and mitogen extracellular

kinase (U 0126). Conclusion: LPS inhibits the mucosal Na(+)-dependent D-galactose intestinal absorption and the Na(+), K(+)-ATPase activity when it is added to the tissue. Intracellular processes related to protein kinases seem to be implicated in the endotoxin effect. Copyright (C) 2008 S. Karger AG, Basel”
“Polyhydroxyalkanoates (PHAs) are accumulated in many prokaryotes. Several members of the Halobacteriaceae produce poly-3-hydroxybutyrate (PHB), but it is not known if this is a general property of the family. We evaluated identification methods for PHAs with 20 haloarchaeal species, three of them isolates from Permian salt. Staining with Sudan Black B, Nile Blue A, or Nile Red was applied to screen for the presence of PHAs. Transmission electron microscopy and (1)H-nuclear magnetic resonance spectroscopy were used for visualization

of PHB granules and chemical confirmation of PHAs in cell extracts, respectively. We report for the first time the production of PHAs by Halococcus sp. (Halococcus morrhuae DSM 1307(T), Bromosporine cost Halococcus saccharolyticus DSM 5350(T), Halococcus salifodinae DSM 8989(T), Halococcus dombrowskii DSM 14522(T), Halococcus

hamelinensis JCM 12892(T), Halococcus qingdaonensis JCM 13587(T)), Halorubrum sp. (Hrr. coriense DSM 10284(T), Halorubrum chaoviator DSM 19316(T), Hrr. chaoviator strains NaxosII and AUS-1), haloalkaliphiles (Natronobacterium gregoryi NCMB 2189(T), Natronococcus occultus DSM 3396(T)) and Halobacterium noricense DSM 9758(T). No PHB was detected in Halobacterium salinarum DZNeP molecular weight NRC-1 ATCC 700922, Hbt. salinarum R1 and Haloferax volcanii DSM 3757(T). Most species synthesized PHAs when growing in synthetic as well as in complex medium. The polyesters were generally composed of PHB and poly–hydroxybutyrate-co-3-hydroxyvalerate (PHBV). Available genomic data suggest the absence of PHA synthesis in some haloarchaea and in all other Euryarchaeota and Crenarchaeota. Homologies between haloarchaeal and bacterial PHA synthesizing enzymes had indicated to some authors probable horizontal gene transfer, which, considering the data obtained in this study, may have occurred already before Permian times.”
“The diversity and cold-active hydrolytic enzymes of culturable bacteria associated with sandy sediment from Nella Fjord, Eastern Antarctica (69 degrees 22’6 ” S, 76 degrees 21’45 ” E) was investigated. A total of 33 aerobic heterotrophic bacterial strains were isolated at 4 degrees C.

The survey indicates that the Chief Nursing Officer review has stimulated some activity in all organisations who responded. Eleven of the recommendations were ranked similarly by trusts and higher education institutions. There were statistically significant differences between trusts and higher education institution priorities

in four areas, inpatient care, evidence-based interventions, multidisciplinary team working and recruitment and retention.\n\nConclusions.\n\nThe findings of the survey demonstrate that all organisations have made some progress in the implementation of the Chief Nursing Officer recommendations. Trusts and higher education institutions broadly agree on the importance of each of the Chief Nursing Officer recommendations, with

HM781-36B purchase the exception of four items. A range of factors was identified by respondents that were perceived as facilitators and barriers to the implementation Cilengitide chemical structure of the Chief Nursing Officer review.\n\nRelevance to clinical practice.\n\nThis article contains findings that are highly relevant for current and future clinical practice in mental health. Despite some progress, clear differences between higher education institutions and trusts are apparent. It is important that these differing perspectives are acknowledged and resolved to improve healthcare provision. Both trusts and higher education institutions reported difficulty with engaging service users and carers. Small molecule library A range of factors are identified that act as facilitators and barriers to the implementation of healthcare policy.”
“Objective: The aim of the study was to carry out a national survey in order to assess young people’s recognition and beliefs about treatment for depression, anxiety disorders and schizophrenia/psychosis.\n\nMethod: In 2011, telephone interviews were carried out with 3021 Australians aged between 15 and 25 years. Participants were presented with a case vignette describing either depression, depression with suicidal thoughts, depression with alcohol misuse, psychosis/schizophrenia, social phobia or post-traumatic

stress disorder (PTSD). Questions were asked about what was wrong with the person, help-seeking intentions and the likely helpfulness of a broad range of interventions.\n\nResults: Rates of recognition of depression were relatively high, with almost 75% of respondents using the correct label. Rates of recognition for the psychosis (schizophrenia) and PTSD vignettes were similar, with around one third of respondents using the correct labels. Only 3% of respondents were able to correctly label social phobia. Intentions to seek help were highest for depression with suicidal thoughts and lowest for social phobia, with family members nominated the most likely sources of help across all vignettes.\n\nConclusions: Most young people believe in the importance of seeking professional help and they have good recognition of depression.