The recent discovery of competitive endogenous RNAs (ceRNA), natural decoys that compete for a common pool of miRNAs, provides a framework to systematically functionalize MRE-harboring noncoding RNAs and integrate them with the protein-coding RNA dimension in complex ceRNA networks. Functional interactions in ceRNA networks aid in coordinating a number of biologic processes and, when perturbed, contribute
to disease pathogenesis. In this review, we discuss recent discoveries that implicate natural miRNA decoys in the development of cancer.\n\nSignificance: Cross-talk between ceRNAs through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such Volasertib as cancer. As cross-talk can be predicted on the basis of the overlap of miRNA-binding
sites, we are now one step closer to a complete functionalization of the human transcriptome, especially the noncoding space. (C) 2013 AACR.”
“Variational transition state theory calculations with the correction of multidimensional tunneling are performed on a 12-dimensional ab initio potential energy surface for the H + SiH4 abstraction reaction. The surface is constructed using a dual-level strategy. For the temperature range 200-1600 K, thermal rate constants are calculated and kinetic isotope effects for various isotopic species of the title reaction are investigated. The results are in very good agreement with available experimental data. (C) 2011 RSL3 concentration American Institute of Physics. [doi:10.1063/1.3521477]“
“This study represents the first survey of the parasitic fauna of cetaceans off the northeastern coast of Brazil. Parasites were collected from 82 animals rescued from the states of Ceara to Bahia, including the archipelago of Fernando de Noronha. A total of 14 species of cetaceans were evaluated: Sotalia guianensis, Stenella sp., Stenella clymene, Stenella longirostris, Stenella coeruleoalba, Stenella frontalis, Megaptera novaeangliae, Peponocephala elect no, Steno bredanensis, Kogia Saracatinib ic50 breviceps, Kogia sima, Globicephala macrorhynchus, Tursiops truncatus, Physeter macrocephalus and Lagenodelphis
hosei. The parasites were fixed and preserved in 70% ethanol or alcohol-formalin-acetic acid solution (AFA), clarified in phenol and mounted on slides for morphological identification. In total, 11 species and 8 genera of endo- and ectoparasites were identified: Halocercus brasiliensis, Halocercus kleinenbergi, Stenurus globicephalae, Halocercus sp., Anisakis sp., Crassicauda sp. (Nematoda), Phyllobothrium delphini, Monorygma grimaldii, Scolex pleuronectis, Strobicephalus triangularis, Tetrabothrius forsteri, Tetrabothrius sp., Trigonocotyle sp., Diphyllobothrium sp. (Cestoda), Corn pub sp. (Trematoda), Bolbosoma sp. (Acanthocephala), Cyamus boopis, Syncyamus pseudorcae and Xenobalanus globicipitis (Crustacea).