Conclusions: This study has exploited available real monthly data

Conclusions: This study has exploited available real monthly data on malaria and climate over 12 years in Burundi to derive and propose a regression modelling to assess climatic factors that are associated with monthly malaria PND-1186 price incidence. The results obtained from the proposed models suggest a strong positive association between malaria incidence in a given month and the minimum temperature (night temperature) of the previous month. An open question is, therefore, how to cope with high temperatures at night.”
“The stabilization of beta-cyclodextrin

(beta-CD) oil spacer polyester fabric (three-dimensional) is ail interesting task. Using a crosslinking agent to stabilize beta-CD oil the spacer polyester fabric is Blebbistatin purchase necessary. This causes an increase in the durability of beta-CD oil the fabric.

In this research, five different c crosslinking agents, including two non-formaldehyde crosslinking agents (citric acid and 1,2,3,4-butane tetracarboxylic acid), one formaldehyde-based crosslinking agent (dimethylol dihydroxyl ethylene urea), and two different commercial siloxane-based softeners, Were used to specify the best yield oil the polyester fabric with beta-CD. The results showed that, among the different crosslinking agents, 1,2,3,4-butane tetracarboxylic acid provided the best durability after 10 washings. The changes in the weight, regain, drop absorption time on the fabric surface, metal-ion (chrome) absorption, and reactive-dye absorption Protein Tyrosine Kinase inhibitor were also reported, and scanning electron microscopy pictures were observed (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 116: 210-217, 2010″
“Some aspects of lateralization are widespread. This is clear for the association between left-eye (LE) use and readiness to respond

intensely to releasing stimuli presented by others, which has been found in representatives of all major groups of tetrapods and in fishes. In the chick, this behavioural asymmetry is linked developmentally to greater ability to sustain response against distracting stimuli with right-eye (RE) use, in that both reverse with the reversal of the normal RE exposure to light. In the zebrafish, the same two asymmetries (normally) have similar associations with the LE and the RE, and both also reverse together (owing to epithalamic reversal). Here, we show that light exposure early in development is needed in zebrafish to generate both asymmetries. Dark development largely abolishes both the enhanced abilities, confirming their linkage. Resemblance to the chick is increased by the survival in the chick, after dark development, of higher ability to assess familiarity of complex stimuli when using the LE. A somewhat similar ability survives in dark-developed zebrafish. Here, LE use causes lesser reliance on a single recent experience than on longer term past experience in the assessment of novelty.

The adverse initial perturbation dominates at a low distribution

The adverse initial perturbation dominates at a low distribution density and thereby making the DWCNTs more susceptible to bending instability. However, the stiffening effect of sp(3) interwall bonding is triggered after a sufficiently large distribution density is reached

and one can expect the bending rigidity of the DWCNTs to improve substantially thereafter with increasing distribution density. (C) 2011 American Institute of Physics. [doi:10.1063/1.3569593]“
“Aortic stiffness and proteinuria are cardiovascular BAY 63-2521 research buy risk factors that are generally associated with each other. We analysed whether this is true for patients with chronic kidney disease (CKD). We hypothesized that in CKD patients of young age and predominant sole renal disease, aortic stiffness has no predictive value for proteinuria. In a cross-sectional setting, 144 patients with severe-to-mild CKD (estimated glomerular filtration rate (eGFR) 0 to <90 ml min(-1) 1.73 m(-2)) were analysed for stiffness, as measured using carotid-femoral pulse

wave velocity (C-F PWV), and proteinuria, as determined using protein-creatinine ratio from morning spot urine. In stepwise linear regression analysis, C-F PWV predicted protein-creatinine ratio and vice versa. Younger patients (<50 years) with proteinuria had predominant glomerulonephritis. These were click here characterized by lower C-F PWV despite similar renal function when compared with younger patients without glomerulonephritis. We conclude that in CKD patients a general relationship exists between aortic stiffness and proteinuria. It is noted that this relation is lost

in young CKD patients with predominant sole renal disease. In this study, C-F PWV is not predictive for proteinuria as renal disease is the leading cause of proteinuria. Journal of Human Hypertension (2010) 24, 593-599; doi:10.1038/jhh.2009.108; published online 28 January 2010″
“Ablation of parahissian SNX-5422 research buy accessory pathways (APs) is a challenging procedure because of the high risk to provoke iatrogenic atrioventricular (AV) nodal block. The feasibility and safety of cryoablation (CA) have been already demonstrated both in patients with AV nodal reentry tachycardia and in those with anteroseptal APs. However, dissociation between anterograde and retrograde conduction after CA has not yet been described. We report two cases of CA of parahissian AP associated with transient dissociation between anterograde and retrograde conduction. (PACE 2011; 34:e98e101)”
“The influence of two different SiO(2) and polymethylmethacrylate (PMMA) gate dielectrics on the performance of single-layered organic field-effect transistors and bi-layered organic light-emitting field-effect transistors was examined.

In particular, we suggest that CS activity has a role in controll

In particular, we suggest that CS activity has a role in controlling the bursts CN neurons show during various movements, during sleep states, and under ketamine-xylazine

MI-503 research buy anesthesia. The ability to perform this role rests on the fact that CSs can be highly synchronized among PCs that project to the same CN neuron. Specifically, we suggest that synchronized CSs help determine the temporal course of the CN bursts, most often their offset, and that SSs and activity from cerebellar afferents may modulate the specific firing pattern within each burst. This joint control of CN activity may help explain anomalies present in the standard model for synaptic control of CN activity in which determination of CN firing patterns is attributed primarily to SSs.”
“Respiratory complication is one of the important postoperative complications of oesophageal cancer. The aim of this study was to evaluate whether neoadjuvant chemotherapy before surgery is effective for postoperative selleck respiratory complications. In this study, patients with

oesophageal cancer were divided into two group: one with neoadjuvant therapy and the other without neoadjuvant therapy. Before surgery, they all underwent bronchoscopy and bronchoalveolar lavage. We evaluated respiratory complications and the effects of preoperative neoadjuvant therapy. Forty patients (M/F = 23/17 and mean age 61 years) were enrolled in this study. Twenty-two cases had cancer in the middle HKI-272 price part and 18 in the lower part of the oesophagus. Significant correlation was observed between the number of positive micro-organism and difficulty in weaning and receiving neoadjuvant therapy. But no significant correlation was found between neoadjuvant therapy and respiratory complications.”
“Methods. aEuro integral A prospective cohort evaluation of the association between Doppler-flow velocity indices of the MCA and ventricular width in singleton fetuses referred because of suspected ventriculomegaly

between 20 and 40 weeks’ gestation. Fetuses that were diagnosed as bilateral or unilateral ventriculomegaly were assigned to the study group and those with normal ventricular width served as controls.

Results. aEuro integral Of the 53 women recruited to the study, in 30 (57%%) fetuses (study group) at least one ventricle >= a parts per thousand yen10 mm was detected, of them 10 (33%%) had bilateral ventriculomegaly and 20 (67%%) had unilateral ventriculomegaly. Of the 30 fetuses 29 had mild ventriculomegaly. In 23 fetuses ventricular width was < 10 mm (control group). Mean MCA pulsatility index (PI) and mean peak systolic velocity (PSV) were not different between the study group and the control group (p == 0.935 and p == 0.743, respectively). In a linear regression model, MCA-PSV was significantly correlated with gestational age, R<SU2</SU == 0.309, p < 0.001.


77% had acute respiratory failure, and several deaths also occurr

77% had acute respiratory failure, and several deaths also occurred. The mean length of hospital stay was 2.8 days. The estimated annual cost of hospitalization selleckchem for pyelonephritis in pregnancy was $263 million. Conclusions: Hospitalization for pyelonephritis in pregnancy is associated with recognizable characteristics including age and diabetes. Serious medical complications

and even mortality can occur.”
“In children, including those aged <5 years, an IGRA is useful as an adjunct. If the child’s IGRA test is positive, it may support diagnosis of active TB. QFT was positive in 83% of the children diagnosed with active TB. Of course, the IGRA should not be used to rule out a diagnosis of TB. However, low rates of IGRA-positives have been reported in studies of young

selleck chemicals children and infants supposedly with LTBI, without active TB. Of four babies (aged 0-6 years) with positive TSTs without BCG history, only two were QFT-G-positive. There is also a case where a mother developed smear-positive TB 2 months after the baby was born. The child’s TST was negative and the QFT was indeterminate. Seven months later the child became TST-positive and the QFT was still indeterminate. In a second case, the mother developed smear-positive TB one month after the baby’s birth and at 3 months the baby was TST-positive and QFT-negative. At 7 months the baby was again QFT tested and still QFT-negative. In one additional piece of relevant data from Japan, looking at BCG-vaccinated contacts in Japan, two of four TST-positive contacts 1-2 years of age were also OFT-positive; seven of 23 TST-positive contacts aged 3-6 years of age were QFT-positive; five of 19 TST-positive contacts

aged 7-12 years of age were also QFT-positive; and five of 7 TST-positive contacts aged 13 to 15 years of age were also QFT-positive. These findings suggest that in the case of LTBI, not TB disease, QFT sensitivity depends on age, and it is higher in older children. Our tentative recommendation for the diagnosis of LTBI in children is that for those aged <5 years, tuberculin testing cannot be omitted, while for the older children QFT is prioritized.”
“Objective: The aim is to evaluate intrapartum fetal oxidative stress in real-time by umbilical cord blood dimethyl sulfate click here (DMSO)-induced ascorbyl free radical (AFR) measured by an electron spin resonance (ESR) method. Methods: 75 mothers delivering at gestational age after 37 weeks were recruited. They were divided into three groups: spontaneous vaginal birth (n = 27), elective cesarean section (CS) (n = 34), and emergency CS due to non-reassuring fetal status (n = 14). Umbilical artery (UA) and venous (UV) cord blood gas analysis was performed. Serum levels of DMSO-induced AFR (AFR/DMSO) that reflect vitamin C concentrations, was measured by ESR spectroscopy. Results: Blood gas analysis showed no significant differences among the groups.

0-7 4)

DiscussionPain was associated with substantial


DiscussionPain was associated with substantially increased odds

of impairment in physical function. Pain should be an important consideration in HIV primary care. Interventions to address pain and impaired physical function should be investigated.”
“Depth-profiled Doppler broadening spectroscopy of positron annihilation on fatigue fracture surfaces of two amorphous Zr(44)Ti(11)Ni(10)Cu(10)Be(25) metallic glass specimens reveals the presence of a layer of increased free volume induced by cyclic deformation, as compared to surfaces that have been etched to remove any surface damage. The damage layer, or fatigue transformation zone (FTZ), is generated by the propagating fatigue crack tip and the deduced size of that zone is similar to the predicted cyclic plastic zone size at a number of locations where the crack grew at different GSK J4 cost stress intensities. The presence of the FTZ is independent of the initial amount of bulk free volume, which was varied between the two specimens by structural relaxation via annealing, and the free volume sites generated in the zone are distinct from those typical of the bulk, as evidenced by the higher S parameter. buy Ganetespib Such observations support the concept that the mechanically induced free volume within the FTZ zone controls the fatigue crack growth rates rather than the initial

free volume of the bulk material. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3120784]“
“Case Description-A 4-year-old spayed female Boxer was evaluated for a cutaneous mass located on the dorsum. The mass had been present for 6 weeks and was increasing in size.

Clinical Findings-A mass of approximately 10 cm in diameter was detected on the dorsum cranial to the right ilial wing. Histologic examination of a tissue sample from the mass led to the diagnosis of cutaneous pythiosis. Computed tomography of the abdomen and the mass were performed and revealed

a contrast-enhancing soft tissue mass of the dorsum and enlarged intra-abdominal lymph nodes.

Treatment and Outcome-The dog underwent Lapatinib in vivo surgical excision of the cutaneous mass, including 5-cm skin margins and deep margins of 2 fascial planes. The mass was completely excised on the basis of results of histologic examination of surgical margins. The dog received itraconazole and terbinafine by mouth for 3 months following surgery. Recheck examination at 20 months postoperatively showed no signs of recurrence of pythiosis at the surgical site.

Clinical Relevance-Aggressive surgical excision in combination with medical treatment resulted in a favorable long-term (>1 year) outcome in this dog. Thorough workup including diagnostic imaging and lymph node evaluation is recommended. If surgery is to be performed, skin margins of 5 cm and deep margins of 2 fascial planes are recommended. (J Am Vet Med Assoc 2011;239;1232-1235)”
“ObjectiveAvailable evidence to help guide efficacious nonsteroidal anti-inflammatory drug and opioid analgesic prescribing will be reviewed.

(C) 2013 European Society for Vascular Surgery Published by Else

(C) 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“This study assesses the effect of passive and active smoking on pregnancy rates after IVF with transfer of high-quality embryos. In a cohort study, women attending the IVF unit in 2006-2007 with favourable parameters for pregnancy (<38 years; less than three IVF cycles, transfer of two highest-grade embryos) grouped by smoking status were included. The cohort included 237 patients/cycles: 42 smokers, 195 non-smokers. The clinical pregnancy rate RSL3 manufacturer was significantly

lower in smokers (35.7% versus 55.4%, P = 0.021, OR = 0.44 (95% CI 0.22-0.89)), even after conditional stratification on covariates (passive smoker, passive or partner smoker, age group). The live-birth rate was lower in smokers (28.6% versus 42.6%), but the difference was not statistically significant (OR = 0.54 (0.26-1.11)). Among non-smokers, there was no difference in pregnancy rate

by passive or partner smoking. On logistic regression, variables predicting pregnancy were age <35 years (P = 0.008, OR = 2.58 (1.2-5.2)) and non-smoking (P = 0.003, OR = 3.47 (1.51-7.98)). In conclusion, transfer of high-quality embryos does not overcome the negative effect of active smoking on pregnancy rate in IVF treatment. The endometrium is apparently involved in the mechanism underlying IVF failure in smokers. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Aim of the study: To compare early and long term results of open and endovascular treatment of Saracatinib clinical trial post-carotid endarterectomy (CEA) restenosis in a single centre experience.

Methods: From January 2005 to December 2011, ninety-nine consecutive interventions

for primary severe post-CEA restenosis were performed: in 41 cases (41%, Group 1) open repair was carried out, whereas the remaining 58 patients (59%, group 2) underwent an endovascular treatment. Data concerning these interventions were prospectively collected in a dedicated database containing main pre, intra and postoperative variables. BIIB057 chemical structure Early results in terms of 30-day stroke and death rates were analysed and compared with chi(2) test. Follow-up results were analysed with Kaplan Meier curves and compared with log-rank test.

Results: Mean time from primary CEA was 75 months in group 1 and 42 months in group 2 (p = 0.002; 95% CI 12-52). There were no differences between the two groups in terms of demographic data, comorbidities, risk factors for atherosclerosis, preoperative clinical status or degree of stenosis on the operated side. In group 1 interventions consisted of redo-CEA in 37 patients and of carotid bypass in the remaining 4; all the patients in group 2 underwent stent placement with cerebral protection device.

Conclusions: This study offers a tool allowing more complete and

Conclusions: This study offers a tool allowing more complete and rapid evaluation of patients with fibromyalgia. The test intrinsically evaluates the emotional aspects: anxiety and depression, and their impact upon social aspects. It also evaluates patient functional capacity, fatigue, sleep LY2606368 in vitro quality, pain, and the way in which the patient copes with the disease. This is achieved by means of a self-assessment

questionnaire based on elements from well known tests.”
“Objective: Cancer patients in Hong Kong and Taiwan share traditional Chinese as a written form of language, but each region has its own sociocultural background. This study examined if the four-factor model (self, spiritual, life orientation, and interpersonal) of the Chinese version of the Posttraumatic Growth Inventory (PTGI-C), developed for Hong Kong cancer LY3023414 datasheet survivors, could be applied to cancer survivors in Taiwan.

Methods: Multisample confirmatory factor analyses (MS-CFA) were used to examine the factorial invariance of the PTGI-C among cancer survivors in Taiwan (n = 217) and Hong Kong (n = 223).

Results: The goodness-of-fit of the four-factor model was satisfactory, chi(2)(180) = 372.36 (chi(2)/df = 2.07), goodness-of-fit index (GFI) = 0.90, adjusted GFI (AGFI) = 0.87, comparative

fit index (CFI) = 0.92, Tucker-Lewis index (TLI) = 0.91, root mean square error of approximation (RMSEA) = 0.05, Akaike information criterion (AIC) = 492.36. This result suggests that the factor structure of the PTGI-C developed in Hong Kong could be applied to cancer survivors in Taiwan. The internal OSI-906 clinical trial reliabilities of the 15-item whole scale, as well as all the subscales, were good and similar to those reported previously. Interregion comparison revealed that the Taiwan sample had higher mean ‘spiritual’ and ‘interpersonal’ posttraumatic growth subscale scores than the Hong Kong sample.

Conclusions: The four-factor model of the PTGI-C is invariant among cancer survivors using traditional Chinese as a written form of the language. The differences in the degree of some posttraumatic growth dimensions may be because of differences in cultural

factors and in psychosocial support for cancer patients between the two regions. Copyright (C) 2011 John Wiley & Sons, Ltd.”
“Purpose: To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of ‘sham irradiation’ and after ionising radiation exposure. Materials and methods: The influence of cell type, cell density, medium volume, medium storage temperature and other methodological aspects on IL-6 and Interleukin-8 (IL-8) release were investigated. In addition, the effects over the time of different doses of gamma irradiation on the clonogenic survival of bystander cells and on the secretion of these cytokines were studied.

(C) 2013 S Karger AG, Basel”
“Purpose: To investigate the i

(C) 2013 S. Karger AG, Basel”
“Purpose: To investigate the incidence and correlates of cocaine injection initiation and the impacts of daily cocaine injection among a cohort of injection drug users.

Methods: Among 1603 participants, from May 1996 to December 2005, risk factors for initiation of cocaine injection among baseline heroin users were determined by Cox proportional hazards regression and correlates of daily cocaine injection by generalized estimating equations.

Findings: Of the 238 individuals who had never injected cocaine, 200 (84%) had at least one follow-up visit and 121 (61%) consequently initiated into cocaine injection, yielding an incidence density

of initiation into cocaine injection of 21.9% (95% confidence interval (121): 17.9-25.8) per 100 person-years. In a multivariate

model, Downtown Eastside (DTES) residence (adjusted hazard ratio (AHR)=2.46, BLZ945 purchase 95% Cl:1.68-3.60) incarceration (AHR = 1,507 95% Cl: 1.01-2.24), requiring help injecting (AHR = 1.57, 95% CI: 0.99-2.49), and binge drug use (AHR = 1.82, 95% Cl: 1.22-2.73) remained associated with initiation into cocaine injection. DTES residence (adjusted odds ratio (AOR) = 1.99, 95% Cl: 1.62-2.46), unstable housing (AOR NVP-LDE225 mouse = 1.28, 95% Cl: 1.04-1.53), incarceration (AOR = 1.29, 95% CI: 1.04-1.60), sex trade involvement (AOR = 1.46, 95% Cl: 1.15-1.85), requiring help injecting (AOR = 2.11, 95% Cl: 1.73-2.58)), borrowing syringes (AOR = 1.81, 95% Cl: 1.35-2.43) and binge drug use (AOR = 2.16, 95% Cl: 1.81-2.58) were independently associated with daily cocaine injection.

Conclusions: The baseline prevalence and subsequent incidence of initiation into cocaine injection was high. Daily cocaine injection was independently associated with a number of health and social harms, including elevated HIV risk behavior.

(c) 2008 Elsevier Ireland Ltd. All rights reserved.”

Optical transfer diagnosis is a novel melanoma detection system that uses morphologic-physiologic mapping.


To further evaluate the potential of optical transfer diagnosis for distinguishing benign from malignant pigmented melanocytic neoplasms.


Ninety-four patients Sapitinib in vitro with pigmented lesions suggestive of melanoma were referred for optical transfer diagnosis. After lesions were scanned with the camera, they were removed for histopathologic examination by two dermatopathologists each. From the recorded images, morphologic-physiologic maps were created with prediction models of light absorption and scattering by chromophores such as hemoglobin, keratin, and melanin at different epidermal and dermal depths. Entropy and relative entropy values derived from the morphologic-physiologic maps and a set of pure morphologic parameters were analyzed for output prediction of melanoma versus nonmelanoma.

Blood and serum were obtained from 81 patients with type 1 diabet

Blood and serum were obtained from 81 patients with type 1 diabetes mellitus (DM1) (20 patients

had long-term good glycemic control [GGC], 61 patients had long-term poor glycemic control [PGC]). Thirty-one healthy children were used as controls. Fructosamine (FAM) was determined by a spectrophotometric method, HbA(1c) was measured Sapitinib by LPLC, serum advanced glycation end-products (s-AGEs) were determined fluorimetrically, and advanced oxidation protein products (AOPP) were measured spectrophotometrically. We observed significantly higher FAM, HbA(1c), s-AGEs and AOPP levels in the patients with DM1 compared with controls, and significantly higher FAM, HbA(1c) and s-AGEs levels in the PGC group compared with the GGC group. AOPP was higher in the PGC group than in the GGC group, but not significantly. In the PGC group we observed significant selleck compound correlations between HbA(1c) and HDL-C (r = -0.306, p = 0.01), HbA(1c) and s-AGEs (r = 0.486, p<0.001), and HbA(1c) and AOPP (r = 0.447, p<0.01). s-AGEs significantly correlated with triacylglycerols (TAG) (r = 0.537, p<0.001) and

AOPP with HDL-C (r = -0.336, p<0.05), TAG (r = 0.739, p<0.001) and s-AGEs (r = 0.577, p<0.001). In conclusion, our results showed both glycative and oxidative stress are increased in the PGC diabetic group compared with controls, they are linked with glycemic control, and probably contribute to the development of diabetic complications. We suggest that the measurement of not only HbA(1c) but also s-AGEs and AOPP may be useful to predict the risk of development of diabetic complications.”
“In this case series report, two patients with cervicogenic headache were selected. After

initial positive response to the greater occipital nerve block, pulse radio-frequency (PRF) was performed on the position of the second cervical ganglion (C2). Two patients reported 100% pain relief lasting for 6 months. The lateral puncture is safer and more comfortable Navitoclax does than the posterior site. This case study demonstrates the effectiveness of PRF to treat cervicogenic headache originating from the C2 nerve. However, we need to further evaluate the results using more samples.”
“The M2e peptide of the H5N1 A/Chicken/Kurgan/05/2005 avian influenza virus was successfully synthesized in transgenic tobacco plants. The amino-terminal segment of the M2 protein, comprised of 22, 30, or 43 amino acids, including the M2e peptide (M122, M130, and M143 variants, respectively), was translationally fused with the N-terminus of beta-glucuronidase in the pBI121 plant expression vector. The nucleotide sequence of the target fragment was synthesized by ligation from synthetic oligonucleotides; its codon composition was adapted for expression in plants. Tobacco plants were successfully transformed with the obtained vectors (pBIM122, pBIM130, and pBIM143, respectively).

“Microvascular network formation is a significant and chal

“Microvascular network formation is a significant and challenging goal in the engineering of large three-dimensional artificial tissue structures. We show here the development of a fully patent, 3D endothelial cell (microvascular) microfluidic network that has a single inlet and outlet, created in only 28 h in a microdevice involving fluid flow equivalent to natural vasculature. Our microdevice features a Milciclib tailored “”multi-rung ladder”" network, a stylized mimic of an arterial-to-venous pedicle, designed to also allow for systematic and reproducible cell seeding. Immunofluorescence

staining revealed a highly contiguous endothelial monolayer (human umbilical vein endothelial cells) throughout the whole network after 24 h of continuous perfusion. This network persisted for up to 72 h of culture, providing a useful template from which the effects of surface chemistry, fluid flow, and environmental conditions on the development of artificial vascular networks ex vivo may be rapidly and robustly evaluated. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3609264]“

The purpose of this study is to evaluate the prescription of essential or futile medications for terminal cancer patients during their final admission.

Materials and Methods


conducted a retrospective review of the medical charts of terminally ill cancer patients admitted to the Hemato-oncology Department of two teaching hospitals from March Ulixertinib 1, 2007 to December 31, 2009. Essential medications were based on the drugs listed by the International Association

for Hospice and Palliative Care, while futile medications were defined when short-term benefit to patients with respect to survival, quality of life, or symptom control was selleck chemicals not anticipated.


A total of 196 patients were included. Among essential medications, strong opioids were the most frequently prescribed drugs during the last admission (62.2% fentanyl, 44.3% morphine), followed by megestrol (46.0%), and metoclopramide (37.2%); 51% of gastric protectors were prescribed with potential futility. Anti-hypertensive and antiglycemic agents were administered to those who experienced arterial blood pressure below 90 mm Hg (47.3%) or presented with a single measurement of fasting glucose below 50 mg/dL (10.7%), respectively. Statins were prescribed to 6.1% (12/196) of patients, and 75% of those prescriptions were regarded as futile.


Our data suggest that effective prescription of essential medications and withdrawal from futile medications should be actively reconciled for improvement of a patient’s end-of-life care.”
“This paper examined the feasibility of a microfluidics chip for cell capturing and pairing with a high efficiency. The chip was fabricated by the polydimethylsiloxane-based soft-lithography technique and contained two suction duct arrays set in parallel on both sides of a main microchannel.