0-7.4).
DiscussionPain was associated with substantially increased odds
of impairment in physical function. Pain should be an important consideration in HIV primary care. Interventions to address pain and impaired physical function should be investigated.”
“Depth-profiled Doppler broadening spectroscopy of positron annihilation on fatigue fracture surfaces of two amorphous Zr(44)Ti(11)Ni(10)Cu(10)Be(25) metallic glass specimens reveals the presence of a layer of increased free volume induced by cyclic deformation, as compared to surfaces that have been etched to remove any surface damage. The damage layer, or fatigue transformation zone (FTZ), is generated by the propagating fatigue crack tip and the deduced size of that zone is similar to the predicted cyclic plastic zone size at a number of locations where the crack grew at different GSK J4 cost stress intensities. The presence of the FTZ is independent of the initial amount of bulk free volume, which was varied between the two specimens by structural relaxation via annealing, and the free volume sites generated in the zone are distinct from those typical of the bulk, as evidenced by the higher S parameter. buy Ganetespib Such observations support the concept that the mechanically induced free volume within the FTZ zone controls the fatigue crack growth rates rather than the initial
free volume of the bulk material. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3120784]“
“Case Description-A 4-year-old spayed female Boxer was evaluated for a cutaneous mass located on the dorsum. The mass had been present for 6 weeks and was increasing in size.
Clinical Findings-A mass of approximately 10 cm in diameter was detected on the dorsum cranial to the right ilial wing. Histologic examination of a tissue sample from the mass led to the diagnosis of cutaneous pythiosis. Computed tomography of the abdomen and the mass were performed and revealed
a contrast-enhancing soft tissue mass of the dorsum and enlarged intra-abdominal lymph nodes.
Treatment and Outcome-The dog underwent Lapatinib in vivo surgical excision of the cutaneous mass, including 5-cm skin margins and deep margins of 2 fascial planes. The mass was completely excised on the basis of results of histologic examination of surgical margins. The dog received itraconazole and terbinafine by mouth for 3 months following surgery. Recheck examination at 20 months postoperatively showed no signs of recurrence of pythiosis at the surgical site.
Clinical Relevance-Aggressive surgical excision in combination with medical treatment resulted in a favorable long-term (>1 year) outcome in this dog. Thorough workup including diagnostic imaging and lymph node evaluation is recommended. If surgery is to be performed, skin margins of 5 cm and deep margins of 2 fascial planes are recommended. (J Am Vet Med Assoc 2011;239;1232-1235)”
“ObjectiveAvailable evidence to help guide efficacious nonsteroidal anti-inflammatory drug and opioid analgesic prescribing will be reviewed.