(C) 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“This study assesses the effect of passive and active smoking on pregnancy rates after IVF with transfer of high-quality embryos. In a cohort study, women attending the IVF unit in 2006-2007 with favourable parameters for pregnancy (<38 years; less than three IVF cycles, transfer of two highest-grade embryos) grouped by smoking status were included. The cohort included 237 patients/cycles: 42 smokers, 195 non-smokers. The clinical pregnancy rate RSL3 manufacturer was significantly

lower in smokers (35.7% versus 55.4%, P = 0.021, OR = 0.44 (95% CI 0.22-0.89)), even after conditional stratification on covariates (passive smoker, passive or partner smoker, age group). The live-birth rate was lower in smokers (28.6% versus 42.6%), but the difference was not statistically significant (OR = 0.54 (0.26-1.11)). Among non-smokers, there was no difference in pregnancy rate

by passive or partner smoking. On logistic regression, variables predicting pregnancy were age <35 years (P = 0.008, OR = 2.58 (1.2-5.2)) and non-smoking (P = 0.003, OR = 3.47 (1.51-7.98)). In conclusion, transfer of high-quality embryos does not overcome the negative effect of active smoking on pregnancy rate in IVF treatment. The endometrium is apparently involved in the mechanism underlying IVF failure in smokers. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Aim of the study: To compare early and long term results of open and endovascular treatment of Saracatinib clinical trial post-carotid endarterectomy (CEA) restenosis in a single centre experience.

Methods: From January 2005 to December 2011, ninety-nine consecutive interventions

for primary severe post-CEA restenosis were performed: in 41 cases (41%, Group 1) open repair was carried out, whereas the remaining 58 patients (59%, group 2) underwent an endovascular treatment. Data concerning these interventions were prospectively collected in a dedicated database containing main pre, intra and postoperative variables. BIIB057 chemical structure Early results in terms of 30-day stroke and death rates were analysed and compared with chi(2) test. Follow-up results were analysed with Kaplan Meier curves and compared with log-rank test.

Results: Mean time from primary CEA was 75 months in group 1 and 42 months in group 2 (p = 0.002; 95% CI 12-52). There were no differences between the two groups in terms of demographic data, comorbidities, risk factors for atherosclerosis, preoperative clinical status or degree of stenosis on the operated side. In group 1 interventions consisted of redo-CEA in 37 patients and of carotid bypass in the remaining 4; all the patients in group 2 underwent stent placement with cerebral protection device.