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Med 2010, 52:55–62.PubMed Competing interests Stefano Togni and Federico Franceschi are employees of Indena SpA, the manufacturer of Meriva®. Giovanni Appendino is a consultant to Indena SpA. Authors’ contributions FD, JR, XV, AP, JT collected study data and followed patients. GA, ST, FF contributed to data interpretation and drafted the manuscript. All Authors have read and approved the final manuscript.”
“Background Megestrol Acetate Postmenopausal women experience physiological changes related to Fludarabine nmr estrogen deprivation. For example, decreased circulating estrogen levels have shown to be associated with menopausal metabolic syndrome with increasing adiposity . In a rat model of metabolic syndrome, ovariectomy worsened its symptoms . Low estrogen levels can also result in systemic inflammation in postmenopausal women . Besides these physiological changes, postmenopausal women also show a reduction in lean body mass, which can partly be explained by insufficient estrogen levels . Estrogen replacement therapy has been attempted to reverse the changes caused by menopause in an effort to decrease its cardiovascular and thrombotic risks  and to preserve bone mineral density . It appears that estrogen plays several significant roles in women’s health.