Various kinds of mutations of ATP7B cause Wilson disease. Wilson disease is a rare genetic disease that can be treated pharmacologically. Recognition and prompt diagnosis are very important, because Wilson disease is fatal if left untreated. In Selleckchem Pexidartinib this review, I summarize the pathogenesis and management of Wilson disease. “
“Background and Aims:  The adjuvant effects of probiotic-containing yogurt on second-line triple therapy

for Helicobacter pylori (H. pylori) infection have not been evaluated. Methods:  A total of 337 patients with persistent H. pylori infection, after first-line triple therapy, were randomly assigned to receive either triple therapy with (yogurt group, n = 151) or without (control group, n = 186) Will yogurt. Triple therapy consisted of 400 mg moxifloxacin q.d., 1000 mg amoxicillin b.i.d., and 20 mg esomeprazole b.i.d. for 14 days. Will yogurt contains Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium longum, and Streptococcus thermophilus. H. pylori eradication was evaluated by the 13C-urea breath test, histology, or the rapid urease test. Results:  The eradication rates by intention-to-treat analysis were 66.7% and 68.9% in the control and yogurt groups, respectively (P = 0.667). The eradication rates by per-protocol

learn more analysis were 78.5% and 86% in the control and the yogurt groups, respectively (P = 0.110). The adverse event rates were 25.3% and 28.5% in the control group and yogurt group, respectively (P = 0.508). Conclusions:  The addition of yogurt containing probiotics to moxifloxacin-containing second-line treatment neither improved H. pylori eradication rates nor reduced the adverse events of treatment. “
“Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression

from cirrhosis to HCC remains unclear. Herein we report the concurrent increase of liver progenitor cells (LPCs) and transforming growth factor-β (TGF-β) in diethylnitrosamine (DEN)-induced rat hepatocarcinogenesis and cirrhotic livers of HCC patients. Using several experimental approaches, including 2-acetylaminofluorene/partial MCE公司 hepatectomy (2-AAF/PHx) and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-elicited murine liver regeneration, we found that activation of LPCs in the absence of TGF-β induction was insufficient to trigger hepatocarcinogenesis. Moreover, a small fraction of LPCs was detected to coexpress tumor initiating cell (T-IC) markers during rat hepatocarcinogenesis and in human HCCs, and TGF-β levels were positively correlated with T-IC marker expression, which indicates a role of TGF-β in T-IC generation. Rat pluripotent LPC-like WB-F344 cells were exposed to low doses of TGF-β for 18 weeks imitating the enhanced TGF-β expression in cirrhotic liver.

Various kinds of mutations of ATP7B cause Wilson disease. Wilson disease is a rare genetic disease that can be treated pharmacologically. Recognition and prompt diagnosis are very important, because Wilson disease is fatal if left untreated. In RG7204 purchase this review, I summarize the pathogenesis and management of Wilson disease. “
“Background and Aims:  The adjuvant effects of probiotic-containing yogurt on second-line triple therapy

for Helicobacter pylori (H. pylori) infection have not been evaluated. Methods:  A total of 337 patients with persistent H. pylori infection, after first-line triple therapy, were randomly assigned to receive either triple therapy with (yogurt group, n = 151) or without (control group, n = 186) Will yogurt. Triple therapy consisted of 400 mg moxifloxacin q.d., 1000 mg amoxicillin b.i.d., and 20 mg esomeprazole b.i.d. for 14 days. Will yogurt contains Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium longum, and Streptococcus thermophilus. H. pylori eradication was evaluated by the 13C-urea breath test, histology, or the rapid urease test. Results:  The eradication rates by intention-to-treat analysis were 66.7% and 68.9% in the control and yogurt groups, respectively (P = 0.667). The eradication rates by per-protocol

Acalabrutinib manufacturer analysis were 78.5% and 86% in the control and the yogurt groups, respectively (P = 0.110). The adverse event rates were 25.3% and 28.5% in the control group and yogurt group, respectively (P = 0.508). Conclusions:  The addition of yogurt containing probiotics to moxifloxacin-containing second-line treatment neither improved H. pylori eradication rates nor reduced the adverse events of treatment. “
“Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression

from cirrhosis to HCC remains unclear. Herein we report the concurrent increase of liver progenitor cells (LPCs) and transforming growth factor-β (TGF-β) in diethylnitrosamine (DEN)-induced rat hepatocarcinogenesis and cirrhotic livers of HCC patients. Using several experimental approaches, including 2-acetylaminofluorene/partial MCE公司 hepatectomy (2-AAF/PHx) and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-elicited murine liver regeneration, we found that activation of LPCs in the absence of TGF-β induction was insufficient to trigger hepatocarcinogenesis. Moreover, a small fraction of LPCs was detected to coexpress tumor initiating cell (T-IC) markers during rat hepatocarcinogenesis and in human HCCs, and TGF-β levels were positively correlated with T-IC marker expression, which indicates a role of TGF-β in T-IC generation. Rat pluripotent LPC-like WB-F344 cells were exposed to low doses of TGF-β for 18 weeks imitating the enhanced TGF-β expression in cirrhotic liver.

“
“Neurologists must entertain a broad differential diagnosis when considering a patient with cavernous sinus syndrome, including neoplasm, trauma, vascular causes, inflammatory processes, and infections. We report the case of a 37-year-old woman initially diagnosed with cavernous sinus syndrome, where subsequent investigations revealed findings of Takayasu’s arteritis, a large vessel vasculitis. The patient also tested positive for perinuclear antineutrophil cytoplasmic antibodies, suggesting the possibility of a vasculitic spectrum disorder although no clinical features of Wegener’s granulomatosis

were present. Criteria for Takayasu’s arteritis and its protean neurologic manifestations are reviewed. This case highlights the spectrum of

vasculitic conditions that may be associated AZD6244 mouse with cavernous sinus inflammation. “
“(Headache 2011;51:287-291) Background.— Dactolisib in vivo Zonisamide, a sulfonamide analog, is an antiepileptic drug with mechanisms of action similar to topiramate. Because of its pharmacodynamic and pharmacokinetics profiles, zonisamide is also potentially suitable for migraine prevention. Methods.— Tolerability and effectiveness of zonisamide for migraine prophylaxis in patients with a good response to topiramate, but interrupting it for intolerable side effects, were evaluated in 34 patients. After a 1-month period of wash-out, patients were treated with zonisamide (up to a 100 mg/day dosage) for 6 consecutive months. Results.— Zonisamide was well tolerated, only 4 (12%) patients reported transient and tolerable side Amisulpride effects. Mean number of days with headache per month was reduced from 14.9 ± 5.3 during the wash-out period to 2.5 ± 0.6 after 6 months of zonisamide (P < .001). We observed a significant reduction in headache severity and disability, as assessed by visual analog scale and migraine disability assessment scale. Finally, when compared with the 1-month period prior to starting zonisamide, a reduced use of analgesics was recorded

at the end of the follow-up. Conclusion.— Our findings support the use of zonisamide as an alternative therapy for migraine prevention in patients with good response, but poor tolerance to topiramate. “
“(Headache 2011;51:923-931) Sex and gender differences in humans are being increasingly recognized not only in experimental pain paradigms but also clinically. Women experience various chronic pain conditions such as headache more than men and evidence differences in pain threshold and pain tolerance experimentally. In addition to biological underpinnings, psychosocial factors such as gender and social role expectations, coping strategies, and affective variables likely contribute to observed sex- and gender-related differences in headache. The present narrative reviews and summarizes extant literature pertaining to these psychosocial factors.

“
“Neurologists must entertain a broad differential diagnosis when considering a patient with cavernous sinus syndrome, including neoplasm, trauma, vascular causes, inflammatory processes, and infections. We report the case of a 37-year-old woman initially diagnosed with cavernous sinus syndrome, where subsequent investigations revealed findings of Takayasu’s arteritis, a large vessel vasculitis. The patient also tested positive for perinuclear antineutrophil cytoplasmic antibodies, suggesting the possibility of a vasculitic spectrum disorder although no clinical features of Wegener’s granulomatosis

were present. Criteria for Takayasu’s arteritis and its protean neurologic manifestations are reviewed. This case highlights the spectrum of

vasculitic conditions that may be associated selleck chemicals llc with cavernous sinus inflammation. “
“(Headache 2011;51:287-291) Background.— Akt inhibitor Zonisamide, a sulfonamide analog, is an antiepileptic drug with mechanisms of action similar to topiramate. Because of its pharmacodynamic and pharmacokinetics profiles, zonisamide is also potentially suitable for migraine prevention. Methods.— Tolerability and effectiveness of zonisamide for migraine prophylaxis in patients with a good response to topiramate, but interrupting it for intolerable side effects, were evaluated in 34 patients. After a 1-month period of wash-out, patients were treated with zonisamide (up to a 100 mg/day dosage) for 6 consecutive months. Results.— Zonisamide was well tolerated, only 4 (12%) patients reported transient and tolerable side oxyclozanide effects. Mean number of days with headache per month was reduced from 14.9 ± 5.3 during the wash-out period to 2.5 ± 0.6 after 6 months of zonisamide (P < .001). We observed a significant reduction in headache severity and disability, as assessed by visual analog scale and migraine disability assessment scale. Finally, when compared with the 1-month period prior to starting zonisamide, a reduced use of analgesics was recorded

at the end of the follow-up. Conclusion.— Our findings support the use of zonisamide as an alternative therapy for migraine prevention in patients with good response, but poor tolerance to topiramate. “
“(Headache 2011;51:923-931) Sex and gender differences in humans are being increasingly recognized not only in experimental pain paradigms but also clinically. Women experience various chronic pain conditions such as headache more than men and evidence differences in pain threshold and pain tolerance experimentally. In addition to biological underpinnings, psychosocial factors such as gender and social role expectations, coping strategies, and affective variables likely contribute to observed sex- and gender-related differences in headache. The present narrative reviews and summarizes extant literature pertaining to these psychosocial factors.

Secondary outcomes were favorable functional outcome (mRS score ≤3) and mortality at 90 days. Of 20 patients, mean age was 62 ± 13 years, median baseline National Institutes of Health Stroke Scale (NIHSS) score 25.5 (IQR 12-28), and median Glasgow Coma Scale score 7 (IQR 6-11). Mean time to IA treatment was 7 ± 2.8 hours. We achieved partial or complete recanalization

in 17/20 patients (85%). selleck chemical At 3 months, 3/20 patients (15%) had a favorable functional outcome and 9/20 patients (45%) were deceased. Combined treatment with IV abciximab and IA tPA yielded a high recanalization rate in patients with BAO. However, functional outcomes were poor, potentially due to late initiation of treatment. Early treatment might improve functional outcome. J Neuroimaging 2012;22:167–171. “
“Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA-P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel-based morphometry (VBM) and Voxel-based relaxometry (VBR) respectively, in MSA-P. Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying

analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA-P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, MYO10 the anterior cerebellar lobes, and the cerebral www.selleckchem.com/products/AZD2281(Olaparib).html cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk.

Negative correlation was demonstrated between T2 and gray and white matter volume. Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA-P. Normalization for atrophy should always be performed in T2 measurements. “
“The detection rate of typical transient global amnesia (TGA) lesions on diffusion-weighted imaging (DWI) can be improved, up to 85% with optimal DWI parameters and imaging time. There is limited evidence that these findings are similar to those observed in large-scale consecutive patients with TGA in clinical practice. Patients with clinically diagnosed TGA underwent magnetic resonance imaging studies, consecutively, with three sets of DWI parameters (standard clinical DWI protocols, the TGA DWI protocol I and the TGA DWI protocol II) in which the resolution, slice thickness, and the time interval between symptom onset of DWI were varied over an 8-year period. TGA lesion detection rates were up to 88% with a modified TGA DWI protocol.

Secondary outcomes were favorable functional outcome (mRS score ≤3) and mortality at 90 days. Of 20 patients, mean age was 62 ± 13 years, median baseline National Institutes of Health Stroke Scale (NIHSS) score 25.5 (IQR 12-28), and median Glasgow Coma Scale score 7 (IQR 6-11). Mean time to IA treatment was 7 ± 2.8 hours. We achieved partial or complete recanalization

in 17/20 patients (85%). Osimertinib At 3 months, 3/20 patients (15%) had a favorable functional outcome and 9/20 patients (45%) were deceased. Combined treatment with IV abciximab and IA tPA yielded a high recanalization rate in patients with BAO. However, functional outcomes were poor, potentially due to late initiation of treatment. Early treatment might improve functional outcome. J Neuroimaging 2012;22:167–171. “
“Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA-P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel-based morphometry (VBM) and Voxel-based relaxometry (VBR) respectively, in MSA-P. Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying

analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA-P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, filipin the anterior cerebellar lobes, and the cerebral Selleck EPZ 6438 cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk.

Negative correlation was demonstrated between T2 and gray and white matter volume. Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA-P. Normalization for atrophy should always be performed in T2 measurements. “
“The detection rate of typical transient global amnesia (TGA) lesions on diffusion-weighted imaging (DWI) can be improved, up to 85% with optimal DWI parameters and imaging time. There is limited evidence that these findings are similar to those observed in large-scale consecutive patients with TGA in clinical practice. Patients with clinically diagnosed TGA underwent magnetic resonance imaging studies, consecutively, with three sets of DWI parameters (standard clinical DWI protocols, the TGA DWI protocol I and the TGA DWI protocol II) in which the resolution, slice thickness, and the time interval between symptom onset of DWI were varied over an 8-year period. TGA lesion detection rates were up to 88% with a modified TGA DWI protocol.

And the authors are surely guilty of hyperbole and alarmism by titling this website their article, “Fructose Takes a Toll. John S. White Ph.D.*, * White

Technical Research, Argenta, IL. “
“Non-alcoholic fatty liver disease (NAFLD) is recognized as the hepatic manifestation of metabolic syndrome and is the most common chronic liver disease in Western countries. NAFLD encompasses a spectrum of conditions ranging from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH) defined histologically by hepatic steatosis, ballooned hepatocytes, Mallory-Denk bodies and variable degrees of fibrosis on liver biopsy. Whereas simple steatosis carries a benign course, individuals with NASH can progress to cirrhosis and hepatocellular carcinoma. Obesity and metabolic syndrome are major risk factors for NASH. There are

currently no approved pharmacologic therapies for NASH. Management includes lifestyle modification (weight loss, diet, exercise) and optimizing control of underlying comorbid features of metabolic syndrome (diabetes, hypertension, dyslipidemia). Patients with NASH and cirrhosis are at risk for hepatocellular carcinoma (HCC) and should be followed with imaging for HCC surveillance. “
“We read with great interest the article by Zhang et al.1 in which the authors demonstrate that pharmacological targeting of the chromatin remodeling enzymes histone deacetylases (HDAC) and poly (ADP-ribose) polymerases inhibit hepatocellular carcinoma (HCC) cell growth. The H 89 mouse authors showed that HCC cells display differential sensitivity to the HDAC

inhibitor SAHA and PARP inhibitor olaparib, and identified two cell lines with sensitive versus resistant phenotype to both enzyme inhibitors, respectively. Moreover, using these compounds they extensively characterize the signaling pathway involved in the repair of DNA strand breaks and in cell survival. Although these findings suggest that combination therapy with both SAHA and olaparib inhibitors may be a strategy for therapy of sensitive HCC cells, there are some aspects that I believe need to be stressed. Poly ADP ribosylation by PARP is indispensable for recruitment and activation of ATP-dependent chromatin remodeler ALC1 (amplified in liver cancer 1).2 ALC1 is Methocarbamol an important oncogene implicated in the pathogenesis of HCC. Aberrant amplification/overexpression of ALC1 is present in about 50% of all HCC cases and ALC1-overexpressing cells exhibit increased colony formation in soft agar and increased tumorigenicity in nude mice.3 HepG2, shown by Zhang et al.1 to be the most responsive cell line to SAHA and olaparib, display much higher ALC1 expression than human HCC tissue.3 It would be interesting to see if the two cell lines described by Zhang et al. express ALC1 and at which levels, and to what extent findings with olaparib are exploitable by clinics in the half of HCC cases that are ALC1 negative. SAHA is an effective inhibitor of HCC growth.

2-4 Interleukin-1β (IL-1β), a proinflammatory cytokine produced mainly by macrophages, has many biological functions that are essential to sterile inflammation initiated by endogenous danger signals, such as the up-regulation of endothelial adhesion molecules for the recruitment of innate immune cells5 and the development of an inflammatory phenotype.6 The secretion of IL-1β by inflammatory cells is largely dependent on a multiprotein complex termed the inflammasome,

which consists of a nucleotide-binding oligomerization domain–like receptor (NLR) molecule and procaspase-1 and BGB324 order mediates the activation of caspase-1.7-10 Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) plays a critical role in the activation of inflammasomes as an adaptor protein that bridges procaspase-1 and inflammasome receptors such as NLR family pyrin domain containing 3 (NLRP3) and absent in melanoma 2.11-13 Indeed, ASC contributes to the immune response through the assembly of inflammasome complexes that activate the downstream effector cysteine protease caspase-1 and result in the generation of active IL-1β and IL-18 from inactive pro–IL-1β and pro–IL-18 precursors. High mobility group box 1

(HMGB1), an evolutionarily conserved and ubiquitously expressed DNA-binding protein in the nucleus of almost all eukaryotic cells, stabilizes nucleosome formation Glutathione peroxidase and facilitates gene transcription, repair, and recombination.14 In addition drug discovery to its nuclear role, extracellular HMGB1, which is known as one of the key endogenous damage-associated molecular pattern molecules, can activate inflammatory pathways. Indeed, macrophage-derived HMGB1 has been shown to mediate delayed endotoxin lethality and acute lung injury in mice.15-17 HMGB1 can also

be released by ischemia-stressed cells,18, 19 and this suggests its role as an endogenous danger signal or alarmin that may engage a diverse receptor repertoire, including TLR2, TLR4, TLR9, and receptor for advanced glycation end products (RAGE), for the initiation of an array of inflammatory responses.3, 20, 21 Although the ASC/caspase-1/IL-1β axis is essential for triggering the inflammation cascade, little is known about its crosstalk with HMGB1. In the present study, we show that ASC mediates caspase-1/IL-1β signaling and promotes HMGB1 to trigger TLR4-driven inflammation. Our results identify a previously unrecognized HMGB1-dependent ASC/caspase-1/IL-1–mediated inflammation response in the mechanism of liver IRI. Male C57BL/6 wild-type (WT) mice (Jackson Laboratory, Bar Harbor, ME) and ASC knockout (KO) mice (bred at the University of California Los Angeles) were used at 8 to 10 weeks of age.

The difference between the results of the two methods have click here significant. The diagnostic value of EUS-FNA combined with flow cytometry is superior to EUS-FNA combined with pathology and cytology for lymphoma, especially for B-cell non-Hodgkin’s lymphoma. Conclusion: EUS-FNA combined with flow cytometry is a high sensitive, specific and accurate method for the diagnosis of B-cell non-Hodgkin’s lymphoma. Key Word(s): 1. EUS guided FNA; 2. Flow cytometry; 3. pathology; 4. lymphoma; Presenting Author: ZHONGZHI LIU Corresponding Author: ZHONGZHI LIU Affiliations: the fourth hospital of Jilin university Objective: To evaluate the curative effects and security of endoscopic injection sclerotherapy

tissue adhesive therapy. Methods: 76 patients who take the endoscopic therapy with gastric Varices and bleeding were retrospeetively studied. Tissues adhesive group 40 cases: saline water + D-TH

mastic + saline water, sclerosing agent +Tissues adhesive group 36 cases: Lauromacrogol + D-TH mastic + saline water. Results: There were no significant differences in the rate of rebleeding between the two groups in three months, six months, (P > 0.05). There were significantly significant differences in the rate of rebleeding between the two groups in one year,(P < 0.05). The rates of effectively eliminate varices and complications were significantly differences among the two groups (P < 0.05). Conclusion: Endoscopic variceal sclerotherapy and injection of tissue adhesive therapy. Are obviously superior to the s tissue adhesive therapy in effeetively eliminating varices and complications and preventting rebleeding. Key Word(s): 1. varices; 2. sclerotherapy; AZD3965 concentration 3. Lauromacrogol;

4. tissue adhesive; Presenting Author: AHMAD NAJIB AZMI Additional Authors: CHAN WAH KHEONG, SANJIV MAHADEVA, GOH KHEAN LEE Corresponding Author: AHMAD NAJIB AZMI Affiliations: Universiti Sains Islam Malaysia; Universiti Malaya; University Malaya Objective: Bowel preparation is vital in a successful colonoscopy. Commonly used large-volume Polyethylene Glycol Electrolyte Carbohydrate Lavage Solution (PEG-ELS) is affecting patients’ compliance and comfort during the process. We conducted a study to compare the effect of split-dose versus whole-dose PEG-ELS on the quality of bowel preparation and patients’ satisfaction. Methods: Outpatient colonoscopy randomized into two groups; one group received conventional 2-litres PEG-ELS on the same day of procedure, another group received a split-dose 1-litre a day before and 1-litre on the procedure day. The quality of bowel preparation is assessed by the endoscopist using Boston Bowel Preparation Scale. The patients were interviewed before the procedure. Results: 273 patients were randomized; 142 (52%) patients received whole-dose PEG-ELS and 131 (48%) patients received split-dose. Data for 268 patients who completed the colonoscopy was analyzed (median age 64 years old, 52% male).

The difference between the results of the two methods have Tyrosine Kinase Inhibitor Library significant. The diagnostic value of EUS-FNA combined with flow cytometry is superior to EUS-FNA combined with pathology and cytology for lymphoma, especially for B-cell non-Hodgkin’s lymphoma. Conclusion: EUS-FNA combined with flow cytometry is a high sensitive, specific and accurate method for the diagnosis of B-cell non-Hodgkin’s lymphoma. Key Word(s): 1. EUS guided FNA; 2. Flow cytometry; 3. pathology; 4. lymphoma; Presenting Author: ZHONGZHI LIU Corresponding Author: ZHONGZHI LIU Affiliations: the fourth hospital of Jilin university Objective: To evaluate the curative effects and security of endoscopic injection sclerotherapy

tissue adhesive therapy. Methods: 76 patients who take the endoscopic therapy with gastric Varices and bleeding were retrospeetively studied. Tissues adhesive group 40 cases: saline water + D-TH

mastic + saline water, sclerosing agent +Tissues adhesive group 36 cases: Lauromacrogol + D-TH mastic + saline water. Results: There were no significant differences in the rate of rebleeding between the two groups in three months, six months, (P > 0.05). There were significantly significant differences in the rate of rebleeding between the two groups in one year,(P < 0.05). The rates of effectively eliminate varices and complications were significantly differences among the two groups (P < 0.05). Conclusion: Endoscopic variceal sclerotherapy and injection of tissue adhesive therapy. Are obviously superior to the s tissue adhesive therapy in effeetively eliminating varices and complications and preventting rebleeding. Key Word(s): 1. varices; 2. sclerotherapy; check details 3. Lauromacrogol;

4. tissue adhesive; Presenting Author: AHMAD NAJIB AZMI Additional Authors: CHAN WAH KHEONG, SANJIV MAHADEVA, GOH KHEAN LEE Corresponding Author: AHMAD NAJIB AZMI Affiliations: Universiti Sains Islam Malaysia; Universiti Malaya; University Malaya Objective: Bowel preparation is vital in a successful colonoscopy. Commonly used large-volume Polyethylene Glycol Electrolyte Selleckchem 5 FU Lavage Solution (PEG-ELS) is affecting patients’ compliance and comfort during the process. We conducted a study to compare the effect of split-dose versus whole-dose PEG-ELS on the quality of bowel preparation and patients’ satisfaction. Methods: Outpatient colonoscopy randomized into two groups; one group received conventional 2-litres PEG-ELS on the same day of procedure, another group received a split-dose 1-litre a day before and 1-litre on the procedure day. The quality of bowel preparation is assessed by the endoscopist using Boston Bowel Preparation Scale. The patients were interviewed before the procedure. Results: 273 patients were randomized; 142 (52%) patients received whole-dose PEG-ELS and 131 (48%) patients received split-dose. Data for 268 patients who completed the colonoscopy was analyzed (median age 64 years old, 52% male).