Thus, they serve as an alternative for prognosis prediction Furt

Thus, they serve as an alternative for prognosis prediction. Furthermore, most patients died of non–tumor-related events, likely related to

increased viral replication and progression of liver disease. In this view, serum HBV-DNA might offer a better prediction value, because liver tissue sampling bias could be avoided. Of note, more patients in this study had genotype B than genotype C, which appears to contradict what previous studies have demonstrated: that genotype C, not genotype B, PF-02341066 mouse is associated with HCC. However, among younger patients, genotype B has also been found to be associated with HCC.30 In this study, most of the patients included were under 60 years of age, because patients receiving surgical resections were more likely Alectinib purchase to be younger. Furthermore, the present data as well as a previous study indicate that genotype C–related HCC is associated with a poorer prognosis and is likely to be more invasive11; this makes it less likely to be associated with resectable HCC, because resectable HCC tends to be less aggressive and is therefore diagnosed at earlier stages. As such,

it was not surprising that more of genotype B but not genotype C was found in the patients of this study, seeing as they had resectable HCCs. In this study, consistent with previous studies, the HBV-DNA level was closely associated with postoperative prognosis, albeit intrahepatic and not serum viral load was measured in this study. Additionally, univariate analysis indicated that genotype C was associated with a poorer prognosis. However, this factor did not appear to be significant in multivariate analysis. It was likely that the contribution of genotype C to the prognosis of HCC was masked by the presence of the BCP mutation, because genotype C was closely associated with the BCP mutation in HBV infection.31 The reason why the BCP mutation was independently linked to hepatocarcinogenesis is not well understood.

This could not be explained by better replication efficiency, because the mutation did not appear to be associated with changes in HBV-DNA levels, and one study revealed that HBV with BCP mutations actually had lower promoter activities.32 A possible explanation MCE is that the reduced promoter activities in BCP mutants help with evasion of host immunity during development of liver cancer. Alternatively, the concurrent amino acid substitutions in the X protein might enhance its oncogenicity. However, the latter possibility has not been supported by experimental evidence to date. Recent studies have shown that pre-S deletion mutants are highly implicated in hepatocarcinogenesis.28, 29, 33 Other studies, however, have demonstrated that pre-S deletions occur often in the stage of chronic active hepatitis, with almost the same frequency as that seen in HCC.

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