This observation holds much importance as miR* molecules are presently thought to follow degradation pathway and are not assigned with any function. Moreover, we could predict targets for these miR* sequences that are generally involved in plant metabolism. Overall, these results shed light on new paradigm of intricate host-pathogen interactions via miRNA pathway. (C) 2010 Elsevier Masson SAS. All rights reserved.”
“The current Spine Focus Issue reflects the collective efforts of members of
the Spine Trauma Study Group, and seeks to summarize as well as critically evaluate many of the key controversies related to the management of spinal trauma and spinal cord injury. Some of the topics discussed in this issue include the optimal timing for surgical intervention in spinal cord injury and central cord syndrome,
Nocodazole mouse the optimal Nutlin-3a manufacturer treatment for both elderly and skeletally mature individuals with odontoid process fractures, management of pediatric spine trauma, rehabilitation strategies for the spinal injured patient, return to play guidelines, and variations in international practice patterns for the management of common spine trauma scenarios. The current Spine issue serves as an update to clinicians on these topics as well as a framework for stimulating new discussion and research in the field as a whole.”
“Background: The primary objective was to describe microbiologically documented infections during induction therapy for acute lymphoblastic leukemia. The secondary objectives were to describe risk factors for microbiologically documented infections and for patients with a febrile episode, to identify risk factors for recurrence of fever or reinitiation of antibiotics.
Methods: This study was a retrospective review of children from 1 to 18 years of age who received induction chemotherapy between March 1997 and September 2006. Microbiologically documented inflections were examined through the induction period.
Results: There were 425 children evaluated. The most common preexisting risk factor for infection
was Down syndrome in 11 children. Of the 425 children, 83 (19.5%) experienced at least one microbiologically documented infection. There were 85 infections consisting of 65 bacterial, 15 viral and 5 fungal infections.
Variables significantly associated with a microbiologically selleck documented infection were pre-existing risk factors (odds ratio [OR]: 3.63; P = 0.01) and neutropenia at initial infectious episode (OR: 1.86; P = 0.03). Factors associated with recurrence of fever and reinitiation of antibiotics after an initial infectious episode were receipt of a 4-drug induction, neutropenia at the initial infectious episode, initial fever documented in hospital, and lack of bone marrow recovery at the time of initial antibiotic cessation.
Conclusions: About 20% of children with acute lymphoblastic leukemia have a microbiologically documented infection during induction.