SLE possess diseasespeci ris such as exacerbation of disease and thromboemboli these must be considered during the treatment and with regard to a later pregnancy. The clinical experience of the Ferti PROTEKT centres in SLE patients as well as rmendations after literature review will be presented in this paper. Materials and methods Nilotinib We retrospectively analyzed the counselling and treatment data from the Ferti PROTEKT register of patients under 0 years of age with a conmed diagnosis of SLE prior to planned CYC treatment during January to November . The numbers of children before CYC and the chosen form of preservation treatment as well as its possibleplications were taken into account. Data on disease activity and comorbidities were not recorded in the network data.
The number of pregnancies after the CYC treatment have not been analyzed for this work as the documentation is still very iplete. The data evaluation was performed descriptively with Orotic acid inhibitor the help of SPSS Version 8 . All data are presented as the mean with standard deviation. Aprehensive search of the Englishlanguage scienti literature Ergosterol 57874 with limitation to fe humans was carried out on PubMed using the following keywords: systemic lupus erythematos autoimmune disea fertility preservation. Case reports or case series were not considered for the rmendations. Only original data publications from prospective and retrospective studies with a medically conmed oue of ovarian preservation were included. Lupus Downloaded from lup.
sagepub at Bobst Libra New York University on March 9, XML Template K:/LUP/LUP d Fertility preservation methods in young women buy Elesclomol with SLE prior to cytotoxic therapy M Henes . Table Mean age of the patients and their number of children at the time of counselling 0 No treatment Number of patients Total:8 GnRHA Ovarian cryo Egg cell cryo Age < 0 years years6 Treatment GnRHA ovarian cryo GnRHA egg cell cryo years5 Mean age Number of children children child children > children 5 years2 Figure Distribution of the individual treatment methods in the 8 counselled patients with systemic lupus erythematosus. cryo: cryoconservati GnRHA: gonadotropinreleasing hormone analogues. Mean number of children Results patients who underwent surgery. A unilateral oophorectomy was performed in one patient. A total of patients were advised prior to planned treatment which would be toxic to the ovari in the time period stated above.
Besides the mostmon diagnoses of haematological malignancies with fertilization patients and solid tumours with 5 , a total of nonmalignant indications for cyctotoxic therapy were acquired. Of the rheumatological autoimmune diseases were present in . The mostmon diagnosis among these patients was SLE with 8 patients . Patients with SLE were counselled in only 1 centres from a total of 9 centres which participate in the network. The following results focus on the counselled SLE patients only. The mean age of the SLE patients was 5 years . The patients had an average of children at the time of data collection; had no childr and only and had one and two children respectively. The patient characteristics are shown in Table . From 8 patients only ve wome counselled at dierent centr did not make use of the fertility preservation methods.