(TIFF 182 KB) References 1. Ohgaki H, Kleihues P: Epidemiology and etiology of gliomas. Acta Neuropathol 2005,

109:93–108.PubMedCrossRef 2. Stewart LA: Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 2002, 359:1011–1018.PubMedCrossRef 3. Lawler SE, Peruzzi PP, Chiocca EA: Genetic strategies for brain tumor therapy. Cancer Gene Ther 2006, 13:225–233.PubMedCrossRef 4. Hendruschk S, Wiedemuth R, Aigner A, Topfer K, Cartellieri M, Martin D, Kirsch M, Ikonomidou C, Schackert G, Temme A: RNA interference targeting survivin exerts antitumoral effects selleck products in vitro and in established glioma xenografts in vivo. see more Neuro Oncol 2011, 13:1074–1089.PubMedCrossRef 5. Yu F, Ng SS, Chow BK, Sze J, Lu G, Poon WS, Kung HF, Lin MC: Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. J Neurooncol 2011, 103:187–195.PubMedCrossRef 6. Berridge MJ, Bootman MD, Roderick HL: Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003, 4:517–529.PubMedCrossRef 7. Berridge MJ, Lipp P, Bootman MD: The versatility and universality of calcium signalling.

Nat Rev Mol Cell Biol 2000, 1:11–21.PubMedCrossRef 8. Putney JW Jr: A model for receptor-regulated calcium entry. Cell Calcium 1986, 7:1–12.PubMedCrossRef 9. Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T: STIM is a Ca2+ sensor essential for Ca2 + -store-depletion-triggered Ca2+ influx. Curr Biol 2005, 15:1235–1241.PubMedCrossRef 10. Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan

MD: STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol 2005, 169:435–445.PubMedCrossRef 11. Spassova MA, Soboloff J, He LP, Xu W, Elafibranor molecular weight Dziadek MA, Gill DL: STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci Chlormezanone USA 2006, 103:4040–4045.PubMedCrossRef 12. Sabbioni S, Barbanti-Brodano G, Croce CM, Negrini M: GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. Cancer Res 1997, 57:4493–4497.PubMed 13. Sabbioni S, Veronese A, Trubia M, Taramelli R, Barbanti-Brodano G, Croce CM, Negrini M: Exon structure and promoter identification of STIM1 (alias GOK), a human gene causing growth arrest of the human tumor cell lines G401 and RD. Cytogenet Cell Genet 1999, 86:214–218.PubMedCrossRef 14. Yang S, Zhang JJ, Huang XY: Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 2009, 15:124–134.PubMedCrossRef 15. Liu H, Hughes JD, Rollins S, Chen B, Perkins E: Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis. Exp Mol Pathol 2011, 91:753–760.PubMedCrossRef 16.