Several features are well correlated with historical tectonic events in this region, such as extension along the North Atlantic Ridge, trench retreat in the Mediterranean, and counterclockwise rotation of the Anatolian Plate. Beneath northeastern Europe, the direction of the fast anisotropic axis follows trends of ancient rift systems older than 350 million years, suggesting “”frozen-in”" anisotropy related to the formation of the craton. Local anisotropic strength profiles identify

the brittle-ductile transitions in lithospheric strength. In continental regions, these profiles also identify the lower crust, characterized by ductile flow. The observed anisotropic fabric

is generally consistent with the current surface strain INCB018424 rate measured by geodetic surveys.”
“Soluble manganese(III) [Mn(III)] can potentially serve as both oxidant and reductant in one-electron-transfer reactions with other redox species. In near-surface sediment porewater, it is often overlooked as a major component of Mn cycling. Applying a spectrophotometric kinetic PD-0332991 clinical trial method to hemipelagic sediments from the Laurentian Trough (Quebec, Canada), we found that soluble Mn(III), likely stabilized by organic or inorganic ligands, accounts for up to 90% of the total dissolved Mn pool. Vertical profiles of dissolved oxygen and dissolved and solid Mn suggest that soluble Mn(III) is primarily produced via oxidation of Mn(II) diffusing upwards from anoxic sediments with lesser contributions from biotic

and selleckchem abiotic reductive dissolution of MnO2. The conceptual model of the sedimentary redox cycle should therefore explicitly include dissolved Mn(III).”
“Ingenol is a diterpenoid with unique architecture and has derivatives possessing important anticancer activity, including the recently Food and Drug Administration-approved Picato, a first-in-class drug for the treatment of the precancerous skin condition actinic keratosis. Currently, that compound is sourced inefficiently from Euphorbia peplus. Here, we detail an efficient, highly stereocontrolled synthesis of (+)-ingenol proceeding in only 14 steps from inexpensive (+)-3-carene and using a two-phase design. This synthesis will allow for the creation of fully synthetic analogs of bioactive ingenanes to address pharmacological limitations and provides a strategic blueprint for chemical production. These results validate two-phase terpene total synthesis as not only an academic curiosity but also a viable alternative to isolation or bioengineering for the efficient preparation of polyoxygenated terpenoids at the limits of chemical complexity.