Prepulse inhibition is heritable and has been associated with polymorphisms in serotonin and dopamine system genes. Prepulse inhibition can be enhanced by nicotine, and therefore it has been proposed that schizophrenia patients smoke to ameliorate their early attentional deficits. The PPI-enhancing effects of nicotine in rodents are strain dependent, suggesting a genetic contribution to PPI within the nicotinic acetylcholine receptor ( nAChR) system. Recent human genetic studies also imply that tobacco dependence is affected by polymorphisms check details in the alpha 3/alpha 5 subunits of the nAChR (CHRNA3/CHRNA5) gene cluster. We, therefore, investigated the

impact of two common CHRNA3 polymorphisms (rs1051730/rs1317286) on PPI, startle reactivity, and habituation of the ASR in two independent samples of 107 healthy British volunteers and 73 schizophrenia patients hailing from Germany. In both samples, PPI was influenced by both CHRNA3 polymorphisms (combined p-value Selonsertib in vivo = 0.0027), which

were strongly linked. Moreover, CHRNA3 genotype was associated with chronicity, treatment, and negative symptoms in the schizophrenia sample. These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia. Neuropsychopharmacology (2010) 35, 1429-1439; doi: 10.1038/npp.2010.12; published online 10 March 2010″
“Behaviorally sensitizing regimen of amphetamine ( AMPH) exposure has diverse effects on learning, memory, and selleck kinase inhibitor cognition that are likely to be a consequence of long-term neural adaptations occurring in the cortico-limbic-striatal circuitry. In particular, altered dopamine signaling in the nucleus

accumbens and medial prefrontal cortex has been implicated to underlie AMPH-induced changes in behavior. This study sought to test the hypothesis that repeated AMPH exposure disrupts the regulation of limbic information processing and the balance of competing limbic control over appetitive behavior. Mice received seven intraperitoneal injections of D-AMPH (2.5 mg/kg or 5 mg/kg) or vehicle solution ( saline) and were trained in ( 1) a simultaneous conditioned cue and place preference task using a six-arm radial maze, found to depend on the integrity of the hippocampus (HPC) and basolateral amygdala (BLA), respectively and ( 2) a conditional BLA-dependent cue, and HPC-dependent place learning task using an elevated T-maze. In both tasks, the vehicle pretreatment group initially acquired cue learning, followed by the emergence of significant place/spatial learning. In contrast, pretreatment with repeated AMPH caused marked deviations from normal acquisition patterns of place and cue conditioning, significantly facilitating HPC-dependent place conditioning in the first task while attenuating BLA-dependent cue conditioning in both tasks.