These effects showed a special sensibility t for microtubule-targeting agents epothilones A and EpOthilone B, which . Taxanes stabilize microtubules and can inhibit tumor cell mitosis, however, the taxane resistance by epothilone treatment, the development LY2608204 of an anti-tumor different overcome. Reactions variables different populations HBCEC partially epothilone A and epothilone B given some specific reactivity t of the tumor in the individual patient. Conclusion Overall, the morphological evaluation and expression of epithelial cytokeratins in primary cells as revealed Rkulturen derived from tumor tissue without significant contamination of other cell types. Zus Tzlich showed long-term culture of tumor biopsies HBCEC populations Preferences Expressed shore cells and some tumor markers are connected, including normal CD24, CD44 and CD227 connected, which was in parallel t too little or no activity And senescence detectable Telomeraseaktivit t.
After all, used HBCEC responded to chemotherapeutic agents for the treatment of breast cancer, although a different reactivities t Was observed in single populations HBCEC. Taken together, these results, optimize the long-term success of the culture of tumor tissue for prime Re HBCEC individualized therapy approach helps. Then k Nnte one repr Sentative number of these individual cultures HBCEC a suitable platform for screening new therapies offer potentially breast cancer. Zus Tzlich long-term culture of tumor tissue for prime Re HBCEC to functional and an opportunity and metabolic Ver Changes of the tumor, including normal characterization of biomarkers suspected Gain Investigate ndnis the mechanism of tumor progression and therefore necessary to consider the potential for development of metastasis capacity t, eg metastases in lymph nodes.
Drugs that are active tubulin in human malignancies and are an essential part of the medical treatment of these diseases. This class of drugs, a variety of drug structures were identified with the periwinkle alkaloids, taxanes, epothilones and received approval for the treatment of cancer. As a result, the pharmaceutical research through connections with tubulin function st Ren agents on the efficiency and reduced toxicity t h improved Focused tte. Search Medline current drug tubulin binding has 430 references. Anything similar research by the National Institutes of Health clinical trials registry http://clinicaltrials.
gov, expressing epothilone lists 108 clinical trials in patients with malignant diseases. The epothilones were in 1987 by the G Tion discovered by soil bacteria found on the banks of the Zambezi River in Africa. A myxobacteria Sorangium cellulosum was found for the production of biologically active substances. One isolate chemical, epothilone A, was found to be high, if the in vitro cytotoxic applied on human T-cell line 24 bladder carcinoma. Natural products are a well known source of new anticancer agents for development and these drugs are generally Selected on the basis of functional screening Hlt.