Latency analyses further suggest that intra-hemispheric processing mediates the influence of S-hand correspondence”
“We aimed to evaluate predictors and mediators of enhancing effect of adjunctive mirtazapine on cognition in schizophrenia. Patients with difficult-to-treat schizophrenia received Anlotinib in vitro either mirtazapine (n = 19) or placebo (n = 18) in a double-blind fashion for six weeks. Mirtazapine outperformed placebo on the Block Design and Stroop Dots. In the present subsidiary study, factors underlying this difference were explored with Path Analysis. Add-on mirtazapine had an independent
enhancing effect on the Block Design-measured visuo-spatial functioning. Further, this effect was mediated via changes in positive, Danusertib depressive and parkinsonism symptoms, but not in negative symptoms. This effect was predicted by higher doses of FGAs, longer duration of illness and lower initial Block Design scores. Path Analysis model fit was good. Mirtazapine may
have direct and indirect favorable effects on visuo-spatial functioning, but further research is needed. Path analysis may be a feasible statistical method for further research of neurocognition in psychopharmacological interventions in schizophrenia.
This article is part of a Special Issue entitled ‘Cognitive Enhancers’. (C) 2012 Elsevier Ltd. All rights reserved.”
“Preparing for a cited, speeded response induces a set of physiological changes A review of the psychophysiology of preparation suggested that inhibition of action was an Important process among the constellation of changes constituting attentive preparation The current
experiment combined event-related functional magnetic resonance Imaging CRT0066101 cell line and cardiac inter-beat interval measures in an experiment that compared preparing for a response, watching stimuli without responding. and responding in the absence of preparation. Ten college-aged participants were tested in an initial psychophysiological experiment followed by two scanning sessions during which reverse spiral imaging was performed concurrent with inter-beat interval measurement. Two analytic approaches were used to confirm blood oxygenation level dependent responses during preparation. and these converged to show Inferior prefrontal and related subthalamic nuclei activity in the context of other known changes related to brain attentional networks. Subthalamic nuclei changes were related to the depth of preparatory Cardiac deceleration.