In this context, tau represents a potential therapeutic target, by the action of drugs that diminish its aggregation, or acting by altering its phosphorylation Belinostat nmr or filaments

formation. There is also anti-tau miscellaneous strategies such as normal microtubule-stabilizing agents. Thus, it might be possible that in a near future the neurodegenerative process could be stopped.”
“Phase compositions and crystal structures of Gd6X2Si3 (X = Ni, Co,) and Ln(6)Co(2)Si(3) (Ln = Pr, La) have been studied. The magnetic properties of Gd6X2Si3 (X = Ni, Co) and Ln(6)Co(2)Si(3) (Ln = Pr, La) have been evaluated from magnetization measurements performed by a superconducting quantum interference device magnetometer in a temperature interval of 5-400 K, and at magnetic fields up to 5 T. The crystal structures of Gd6X2Si3 (X = Co, Ni) and Ln(6)Co(2)Si(3) (Ln Pr, La) were found to be hexagonal at 300 K. The Curie temperature (T-C), effective and magnetic moment of the compounds (at 5 K) have been determined for Gd6X2Si3 (X = Ni, Co), and Ln(6)Co(2)Si(3) (Ln = Pr, La). T-C was found to depend on composition, and reaches maximum value of about 300 K for the Gd6X2Si3 system. The magnetocaloric effect (magnetic entropy changes

and relative cooling power (RCP) was found to depend on X and Ln, and the maximum RCP values were found to be larger than 500 J/kg near room temperature for the Gd6Ni2Si3 and Gd6Co2Si3 compounds. This value of RCP is comparable to the prototype magnetic refrigeration material, Gd. (C) 2011 American Institute www.selleckchem.com/products/CAL-101.html of Physics. [doi:10.1063/1.3544509]“
“Generalized spike and wave discharges (GSW) are often accompanied by transitory cognitive impairment (TCI). As a possible neurophysiological correlate

of TCI, activation in the thalamus and deactivation in the frontoparietal brain regions associated with GSW were discussed in previous studies which used simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with absence epilepsy. We report on a girl having GSW up to 10 seconds without any clinical concomitants. The girl underwent an EEG-fMRI investigation with simultaneous behavioral testing (continuous performance task). Although GSW repeatedly occurred during the task, no TCI was observed. EEG-fMRI revealed bilateral deactivation in frontoparietal brain areas and activation find more in the thalamus in association with GSWs. This study challenges the relation between cognitive impairment during absences and the characteristic pattern of thalamic activation and deactivation in frontoparietal areas associated with GSW. (C) 2010 Elsevier Inc. All rights reserved.”
“Background: At 3 years after diagnosis, the risk of Alzheimer disease (AD) for patients with mild cognitive impairment (MCI) is estimated to be 18% to 30%. To improve treatment of patients at high dementia risk there is a need for a better prediction of the risk for transition from MCI to AD. Olfactory deficits are a hypothetical predictor of conversion form MCI to AD.