1,4-dioxane: water were 0.25, 0.33 and 0.40 ml If the volume of a drop and of protected PROTECTED diameter of the thin film can calculate the film thickness and the surface chemical-volume ratio ratio of the thin film lengths can be approached. For example, for a 1,4-dioxane drops, h V / cm 0.0318. Therefore, the surface GDC-0449 Vismodegib Surface of the thin film SA 2 R2 2 R 1.67 cm H 2 Fl Surface and volume is 67 In a similar manner, the thickness of a thin film based on 1,4-dioxane 50:50: Water is 0.0164 cm and the surface chemical-volume ratio ratio is 124, and the thickness of a thin film based 1, 4-dioxane 20:80: 0.0199 cm and the effective surface of the water ratio Volumenverh 103. because the concentrations of the liquid feed L solutions were the same, smaller range of Volumenverh ratios are in aggregated particles with low surface surface lead.
Moreover, the film thickness, H is used, and therefore dioxane Ren 1.4 to 20:80 explained: water films remained intact in the form of thin flakes w during the lyophilization from 1,4-dioxane 50:50: water films . There were more particles of the transition in the sense that the flakes h is somewhat stiffer, reducing it to a fine powder soft. The degree of crystallinity t of solid dispersions FFT PVP HRV was observed to be directly proportional to the amount of the w Uncircumcised L Used solution in the liquid feed. One explanation Tion for both Ph Phenomena is proposed. First, the water has a low vapor pressure of 1,4-dioxane, and therefore more difficult to remove, may need during the lyophilization, in particular the amount of bound water in the second drying.
Since water acts as a plasticizer in solid dispersions and reduced Tg and physical stability t of the amorphous composition, it is likely that the w Made ssrige formulations of organic co-systems h Higher residual water content resulting in a degree of recrystallization had HRV amorphous. Secondly, HRV, PVP and amorphous materials are hygroscopic. With the increase of the liquid Surface for the absorption of moisture, there is a gr Ere probability of recrystallization in amorphous solid dispersions with very big, he surface Surface. For HRV FFT formulations in the crystal growth w Revealed during the lyophilization, the composition of the L could System solvent by no influence on sub-Saharan Africa since the nanostructure can not be maintained without a polymeric stabilizer.
However, the same observations were made during the w FFT process: better distribution of the droplets with the Tr w ssrigen system organic co-L simulant. However, the composition of the L System solvent by the same effect on the macroscopic appearance of powder formulations showed both crystalline and amorphous. The reason for the significant agglomeration of powders processed FFT produces 100% 1,4-dioxane is not apparent. When comparing the effect of the composition of the L Solvent by which processes on the aerodynamic behavior of the FFT powder, there is a tendency that the macroscopic properties / volume impact of the FPF, with formulations of 1,4-dioxane produced 100% to make the best but the differences were not significant for the group of crystalline or amorphous group. Therefore, the data show that the largest SSA Significant influence on the fine particle fraction, which sheared the lungs, low density, the aggregated particles in situ from the DPI Handihaler.