Conclusion: Taken together, these results suggest the protective role of endogenous VASH1 on A-II-induced

glomerular as well as tubulointerstitial alterations via regulating inflammation and fibrosis and protecting podocytes, and thus suggesting its beneficial effects on hypertensive nephrosclerosis. MAEDA KUNIHIRO1,2,3, KIKUCHI SHOGO3, MIURA NAOTO2, SUZUKI KEISUKE2, KITAGAWA WATARU2, MORITA HIROYUKI2, BANNO Autophagy Compound Library mouse SHOGO2, IMAI HIRIKAZU2 1Division of Nephrology, Department of Internal Medicine, Narita Memorial Hospital; 2Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine; 3Department of Public Health, Aichi Medical University School of Medicine Introduction: In

order to clarify which clinical and pathological factors are predictive of decreased estimated glomerular filtration rate https://www.selleckchem.com/products/ch5424802.html (eGFR) at 5 and 10 years in IgA nephropathy patients, we analyzed retrospective cohort study in single center. Methods: 57 patients with IgA nephropathy who have been followed up the 5 to 10 years after renal biopsy were included in this study, out of the 229 patients with IgA nephropathy admitted to Aichi Medical University Hospital between 1986 and 2010. Clinical, laboratory, and pathological parameters (the number of global sclerosis, focal segmental sclerosis, glomerular tip adhesion, total adhesion, and crescent formation) were analyzed by multiple linear regression analysis with backward elimination to determine independent risk factors. After identifying such factors, we compared patients with and without each factor using the Student’s t test, Wilcoxon test, or Mann–Whitney U test. Results: Four variables (initial eGFR (p = 0.0002), glomerular tip adhesion (p = 0.004), global sclerosis (p = 0.019), and diastolic blood pressure (p = 0.024)) were identified as predictive factors for progression of IgA nephropathy. The annual decrease in eGFR of patients with (n = 9)

or without glomerular tip adhesions (n = 48) was 4.13 ± 3.58 and 1.49 ± 2.89 ml/min/1.73 m2, respectively (p = 0.015). Serum Edoxaban total cholesterol levels were 231 ± 45 mg/dl and 196 ± 42 mg/dl, respectively (two-sided p = 0.064; one-sided p = 0.032). Conclusion: The presence of glomerular tip adhesions predicts the progression of IgA nephropathy. Hypercholesterolemia may affect glomerular tip adhesions. KATAOKA HIROSHI1, OHARA MAMIKO2, MOCHIZUKI TAKAHIRO2, NITTA KOSAKU1 1Department of Medicine, Kidney Center, Tokyo Women’s Medical University, Tokyo, Japan; 2Department of Nephrology, Kameda Medical Center, Kamogawa, Chiba, Japan Introduction: Reliable markers to predict prognosis of IgA nephropathy are still lacking. We have reported maximal glomerular diameter (Max GD), an indicator of glomerular size, as a predictor of the long-term evolution of renal histopathology in 2011.