At 12-year follow-up, the longest reported in a patient this young, the transferred bone had grown much like the native mandible, and the patient had adequate mandibular contour and function. No revisions were needed, although orthopedic surgery was performed to correct an ankle valgus deviation on the donor leg. It is the opinion of

the authors Selleckchem Olaparib that microsurgical mandible reconstruction in very young patients is efficient and that the surrounding structures contribute to the remodeling of the bone segment to achieve characteristics similar to those of the native mandible. © 2013 Wiley Periodicals, Inc. Microsurgery 34:51–53, 2014. Head and neck reconstruction has evolved dramatically with flap anatomy studies and microsurgical techniques. In our

institution, the fibular osteocutaneous free flap is the preferred reconstructive option for mandible defects needing vascularized bone.[1] Pediatric tumors U0126 mouse that require wide excision and complex reconstruction are rare and challenging. The purpose of this article is to report the successful mandibular reconstruction in an 8-month-old girl with a fibular osteocutaneous free flap with a 12-year follow-up. An 8-month-old girl presented to our hospital with a large solid blue mass on her right mandible (Fig. 1). The mass had appeared a few months after birth and grew rapidly. Preoperative biopsy showed that the lesion was a melanotic neuroectodermal tumor, also referred to as melanotic progonoma. Because of the size and biological behavior of the tumor, the head and neck team decided to perform a right hemimandibulectomy, including the condyle and part of the central left mandible, with removal of the mucosa covering the lesion (Fig. 2). A right fibular osteocutaneous free flap was harvested to reconstruct the mandible (Figs. 3 and 4). As much of the fibula was harvested Phosphoprotein phosphatase as possible so as to preserve the growth centers, and portions thought to be sufficient to maintain joint stability were left proximally and distally.The length of the fibular segment was 8.9 cm and the dimensions of the

corresponding skin paddle were 4.5 × 2.1 cm2. The facial vessels were used as recipient vessels with end-to-end microsurgical anastomosis. A single greenstick osteotomy was performed to reproduce the jaw angle. The authors decided not to perform more osteotomies due to the risk of losing skeletal stability, jeopardizing vascularization of the flap and damaging the growth centers. The fibula was then secured to the native mandible with interosseous wiring. The other end of the fibula was positioned in the direction of the glenoid fossa with a 3–0 vicryl stitch. The skin paddle was used to replace the mucosal defect. The donor site was treated with a full-thickness skin graft and occlusive dressing. The patient had a satisfactory recovery.