Of the 17 publications, 15 were published in English and only 2 were written in Chinese. The sample sizes ranged from 185 to 1210. All cases were histologically confirmed. The controls were primarily healthy Selleckchem Bromosporine populations and matched for age, ethnicity, and smoking status. There were 5 groups of Asians, 10 groups of Caucasians, and 2 mixed populations. All polymorphisms in the control subjects were learn more in Hardy-Weinberg equilibrium. Meta-analysis results Table 2 listed the main results of this meta-analysis. Overall, for the T allele carriers (TC + TT) versus homozygote CC, the pooled OR for all studies combined 4123

cases and 5597 controls was 0.95 (95% CI = 0.87-1.04 P = 0.228 for heterogeneity) (Figure 1), for TT versus CC the pooled OR was 0.99 (95% CI = 0.86-1.15 P = 0.315 for heterogeneity). For all studies in the meta-analysis, AG-120 supplier significantly risks were not found for the T allele carriers (TC + TT) versus homozygote CC or TT versus CC, and no heterogeneity was found in all

studies. Table 2 Summary ORs for various contrasts of XRCC3 Thr241Met gene polymorphisms in this meta-analysis Subgroup analysis exon7 genotype Contrast studies OR(95%) Ph Total T/T vs C/C 17 0.99(0.86-1.15) 0.315 (C/T + T/T) vs C/C 0.95(0.87-1.04) 0.228 Ethnicity       Asian T/T vs C/C 5 0.92(0.71-1.09) 0.216 (C/T + T/T) vs C/C 0.94(0.77-1.15)

0.545 Caucasian T/T vs C/C 10 0.94(0.87-1.13) 0.090 (C/T + T/T) vs C/C 0.95(0.85-1.06) 0.056 Mixed population T/T vs C/C 2 1.04(0.77-1.43) 0.190 (C/T + T/T) vs C/C 1.00(0.73-1.37) 0.823 Histological type       SCC T/T vs C/C 2 0.94(0.78-1.58) 0.164 (C/T + T/T) vs C/C 0.91(0.48-1.74) 0.215 AC T/T vs C/C 3 1.09(0.72-1.38) 0.535 (C/T + T/T) vs C/C 1.05(0.79-1.40) Ibrutinib clinical trial 0.331 Smoking status       Smoker T/T vs C/C 4 0.98(0.72-1.45) 0.006 (C/T + T/T) vs C/C 0.93(0.63-1.37) 0.001 Non-smoker T/T vs C/C 4 0.99(0.78-1.51) 0.230 (C/T + T/T) vs C/C 0.92(0.62-1.37) 0.186 Ph P value of Q-test for heterogeneity test. Figure 1 Forest plot (random-effects model) of lung cancer risk associated with XRCC3 Thr241Met polymorphisms for the (C/T + T/T) versus vs C/C. Each box represents the OR point estimate, and its area is proportional to the weight of the study. The diamond (and broken line) represents the overall summary estimate, with CI represented by its width. The unbroken vertical line is set at the null value (OR =1.0). In the stratified analysis by ethnicity, significantly risks were not found among Asians for (TC + TT) versus CC (OR = 0.94, 95% CI = 0.77-1.15; P = 0.545 for heterogeneity) or TT versus CC (OR = 0.92; 95% CI = 0.71-1.09; P = 0.216 for heterogeneity).