2012], we would suggest all women prescribed antipsychotics with raised prepregnancy/first trimester BMI should be offered this test. In addition, it would be potentially helpful to consider the creation of an international register to monitor routinely the maternal and foetal outcomes of antipsychotic use in pregnancy [Kulkarni et al. 2008]. Footnotes Consent: The patient in question has signed an informed consent form allowing publication of the following case report
in any medical journal in print, online and in other licensed versions of the journal. Form available on request. Funding: This research learn more received no specific grant from any funding agency in Inhibitors,research,lifescience,medical the public, commercial, or not-for-profit sectors. Conflict of interest statement: LMH is supported
by the UK Higher Education Funding Council for England. All other authors are employed by the UK National Health Service. LMH has a grant on antipsychotics in Inhibitors,research,lifescience,medical pregnancy from Tommy’s the Baby Charity supported by Johnson and Johnson. DT has provided consultancy to Lundbeck and Inhibitors,research,lifescience,medical Merck, has received honoraria from Eli Lilly, AstraZeneca and Bristol-MyersSquibb, and his institution has received money from Servier and Eli Lilly. SH has received money for consultancy work for LEK consulting. No other authors declared a conflict of interest. Contributor Information Melissa Rowe, Section of Women’s Mental Health, Institute of Psychiatry, King’s College London, UK. Bharath A. Gowda, Department of Neonatology, King’s Inhibitors,research,lifescience,medical College Hospital, London, UK. David Taylor, Institute of Pharmaceutical Science, King’s College London, UK. Simon Hannam, Department of Neonatology, King’s College Hospital, London, UK. Louise M. Howard, Section of Women’s Mental Health, PO31, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.
In this issue Elizabeth Penn and Derek Tracy review in great detail the effects of antidepressants in an article headed ‘The drugs don’t work?’. The question mark is important: Penn Inhibitors,research,lifescience,medical and Tracy conclude that drugs
do work but only after a delay and not in everyone. Much of their discussion centres on the now famous analysis of Irving Kirsch who postulated that antidepressants were only really more effective than placebo in the most severe depression [Kirsch et al. 2008]. Of course what is often forgotten is that placebo is itself a potent antidepressant with an effect size (0.92, according to Kirsch) greater than most medical treatments. MycoClean Mycoplasma Removal Kit In addition to this, Kirsch’s definition of a clinically significant difference is three points on the Hamilton Depression Rating Scale (HDRS). This makes no sense at all because the HDRS is an ordinal scale: someone with a score of 20 is not twice as depressed as someone with a score of 10. Moreover, a three-point difference on the suicide item of the HRDS is a very different thing from a difference of three points on sleep items.