Study Design: A case-control study. Setting: Taiwan. Patients: We used
administrative claims data from the Taiwan National Health Insurance program to identify 2,436 subjects with SSNHL and to randomly select 7,308 controls. Main Outcome Measures: A conditional logistic regression analysis was conducted to calculate the odds ratio (OR) for having been previously diagnosed with CP between cases and controls. Results: In total, 1,663 (17.1%) of the 9,744 sampled subjects had received a CP diagnosis before the index date; 520 (21.4%) were cases and 1143 (15.6%) were controls. The W 2 test suggested that there was a significant difference in the prevalence of previous SSNHL between cases and controls (p smaller than 0.001). The conditional logistic regression revealed after adjusting for hypertension, CDK inhibitor diabetes, hyperlipidemia, renal disease, coronary heart disease, obesity, and stroke, the OR of having previously received a CP diagnosis among cases was 1.44 (95% CI = 1.29 similar to 1.63) that of controls. Conclusion: This study found that SSNHL was significantly
associated with a previous diagnosis of CP. Further LOXO-101 prospective studies are warranted to confirm our findings and clarify the underlying pathomechanism.”
“The reduced folate carrier (RFC1) plays a crucial role in mediating folate delivery into a variety of cells. RFC1 polymorphism (A80G) has been reported to be associated with increased risk of neural tube defects (NTDs). However, results derived from individually underpowered studies are conflicting. We performed a systematic search of MEDLINE
and EMBASE databases and carried out a meta-analysis on the association between RFC1 polymorphism (A80G) selleckchem and NTDs risk. Overall, a significant correlation between RFC1 A80G polymorphism and NTDs risk was found neither in infants nor in maternal (allele contrast in infants: ORRE = 1.15.95% CI: 0.92-1.45: allele contrast in mothers: ORRE = 124, 95% CI: 0.98-1.56). The present meta-analysis failed to support a positive association between RFC1 A80G polymorphism and susceptibility to NTDs. It is important to realize, however, that socioeconomic factors, and gene-environment and gene-gene interactions, could have influenced the outcome of our meta-analysis. For this reason, a relationship between the A80G polymorphism and NTD risk cannot be entirely discounted. (C) 2012 Elsevier B.V. All rights reserved.”
“Background: A subset of subjects with atopic dermatitis (AD) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum.\n\nObjective: This National Institute of Allergy and Infectious Diseases-funded multicenter study was performed to establish a database of clinical information and biologic samples on subjects with AD with and without a history of eczema herpeticum (ADEH(+) and ADEH(-) subjects, respectively) and healthy control subjects.