J Biol Chem 2010,285(53):41961–41971.PubMedCrossRef 206. Djordjevic B, Stojanovic S, Conic I, Jankovic-Velickovic L, Vukomanovic P, Zivadinovic R, Vukadinovic M: Current approach to epithelial ovarian cancer based on the concept of cancer stem cells. J BUON 2012,17(4):627–36.PubMed 207. Chefetz I, Alvero AB, Holmberg JC, Lebowitz
N, Craveiro V, Yang-Hartwich Y, Yin G, Squillace L, Gurrea Soteras M, Aldo P, Mor G: TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence. Cell Cycle 2013,12(3):511–21.PubMedCrossRef 208. Kang KS, Choi YP, Gao MQ, Kang S, Kim BG, Lee JH, Kwon MJ, Shin YK, Cho NH: JNJ-26481585 in vitro CD24(+) ovary cancer cells exhibit an invasive mesenchymal phenotype. Biochem Biophys Res Commun 2013,432(2):333–8.PubMedCrossRef Competing interests The authors declare that they have MRT67307 manufacturer no competing interests. Authors’ contributions FT and AP were the main authors of the manuscript; LR and MS collected and studied the bibliography; PV participated in the sequence alignment and drafted the manuscript; GL corrected the language form; ST drafted the article and revised it critically for important intellectual content. All authors read and approved the final manuscript.”
“Introduction The sentinel lymph node (SLN) is
the first lymph node reached by metastasizing cancer cells from a Cell Cycle inhibitor primary tumor. The lymphatic metastasis in melanoma always proceed sequentially involving cancer cell spreading from the primary site to regional nodes then to distant sites. In 1992 Morton et al. have demonstrated that it is rare that melanoma cells skip the sentinel lymph node and metastasize
in other nodes . Consequently, since its introduction into clinical practice, SLN biopsy has become a widely accepted procedure for predicting the status of regional lymph nodes [2, 3]. The presence of SLN metastases is the strongest prognostic factor for melanoma and the histological status of the sentinel node has repeatedly shown to provide excellent prognostic information with respect to cancer spreading, disease–free and overall survival rate . Current standards of practice suggest Phenylethanolamine N-methyltransferase completion lymphatic node dissection (CLND) for all the patients with a positive SLN, whereas patients with negative SLN are considered to be at lowest risk of further lymph node extension. CLND aims to increase the local control of disease, survival improvement as well as staging patients. However, several studies have also demonstrated that only 20% of patients with a positive SLN will have further (Non-SLN) metastasis at CLND [5, 6]. Although the impact of early dissection of subclinical micrometastatic nodes is well documented on the overall survival rate [7–9], most of the patients don’t present nodal involvement.